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Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications

Record type: Article

Background: National Institute of Clinical Excellence guidelines advocate the use of the Mini-Mental Test Examination and a functional assessment as a means of measuring treatment response. However, there is little knowledge of the change expected in those with Alzheimer's disease in clinical practice.
Objective: to describe the long-term variability of the Mini-Mental Test Examination and Blessed Dementia Rating Scale.
Method: 374 Alzheimer's disease patients referred to psychiatric services in southeast London were followed annually over a 3-year period.
Results: the mean Mini-Mental Test Examination score for the total group at baseline was 9.9 points. Individual variability in the rate of cognitive and functional decline is large and around 40% of patients after 1 year, and up to one-quarter of patients after 3 years who survived, show no change or an improvement in scores compared with baseline measures.
Conclusions: in the evaluation of individual treatment response the rate of change, as measured by the Mini-Mental Test Examination and Blessed Dementia Rating Scale, is of limited value.

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Citation

Holmes, Clive and Lovestone, Simon (2003) Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications Age and Ageing, 32, (2), pp. 200-204.

More information

Published date: 2003
Keywords: alzheimers disease, cognitive decline, national Institute of clinical excellence, functional decline

Identifiers

Local EPrints ID: 27599
URI: http://eprints.soton.ac.uk/id/eprint/27599
ISSN: 0002-0729
PURE UUID: e5cd14be-601c-4fd9-aa7f-b04d4c6b36ed

Catalogue record

Date deposited: 27 Apr 2006
Last modified: 17 Jul 2017 16:04

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