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Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men

Record type: Article

We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (< or = 20 CAG repeats) were associated with AD (adjusted odds ratio = 2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (< 65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.

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Citation

Lehmann, D.J., Butler, H.T., Warden, D.R., Combrinck, M., King, E., Nicoll, J.A.R., Budge, M.M., de Jager, C.A., Hogervorst, E., Esiri, M.M., Ragoussis, J. and Smith, A.D. (2003) Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men Neuroscience Letters, 340, (2), pp. 87-90. (doi:10.1016/S0304-3940(03)00069-7). (PMID:12668243).

More information

e-pub ahead of print date: 15 March 2003
Published date: 10 April 2003
Keywords: sex steroids, estrogen, testosterone, neuroprotection, gender, x chromosome, apolipoprotein e 4, butyrylcholinesterase k variant

Identifiers

Local EPrints ID: 27637
URI: http://eprints.soton.ac.uk/id/eprint/27637
ISSN: 0304-3940
PURE UUID: bbce2986-c486-4ef0-adc1-48dcb8b16791
ORCID for J.A.R. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 27 Apr 2006
Last modified: 17 Jul 2017 16:04

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Contributors

Author: D.J. Lehmann
Author: H.T. Butler
Author: D.R. Warden
Author: M. Combrinck
Author: E. King
Author: J.A.R. Nicoll ORCID iD
Author: M.M. Budge
Author: C.A. de Jager
Author: E. Hogervorst
Author: M.M. Esiri
Author: J. Ragoussis
Author: A.D. Smith

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