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Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men

Lehmann, D.J., Butler, H.T., Warden, D.R., Combrinck, M., King, E., Nicoll, J.A.R., Budge, M.M., de Jager, C.A., Hogervorst, E., Esiri, M.M., Ragoussis, J. and Smith, A.D. (2003) Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men Neuroscience Letters, 340, (2), pp. 87-90. (doi:10.1016/S0304-3940(03)00069-7). (PMID:12668243).

Record type: Article


We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (< or = 20 CAG repeats) were associated with AD (adjusted odds ratio = 2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (< 65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.

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e-pub ahead of print date: 15 March 2003
Published date: 10 April 2003
Keywords: sex steroids, estrogen, testosterone, neuroprotection, gender, x chromosome, apolipoprotein e 4, butyrylcholinesterase k variant


Local EPrints ID: 27637
ISSN: 0304-3940
PURE UUID: bbce2986-c486-4ef0-adc1-48dcb8b16791
ORCID for J.A.R. Nicoll: ORCID iD

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Date deposited: 27 Apr 2006
Last modified: 17 Jul 2017 16:04

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Author: D.J. Lehmann
Author: H.T. Butler
Author: D.R. Warden
Author: M. Combrinck
Author: E. King
Author: J.A.R. Nicoll ORCID iD
Author: M.M. Budge
Author: C.A. de Jager
Author: E. Hogervorst
Author: M.M. Esiri
Author: J. Ragoussis
Author: A.D. Smith

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