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Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men

Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men
Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men
We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (< or = 20 CAG repeats) were associated with AD (adjusted odds ratio = 2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (< 65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.
sex steroids, estrogen, testosterone, neuroprotection, gender, x chromosome, apolipoprotein e 4, butyrylcholinesterase k variant
0304-3940
87-90
Lehmann, D.J.
25e73037-b0dc-4dbb-85ff-ba4fcb90637a
Butler, H.T.
6ba68674-c45f-4920-838b-774ca6601cfa
Warden, D.R.
d360fee1-0842-48f3-8f0c-b43826cea589
Combrinck, M.
b1a6ab1b-dc44-4aaa-9c71-34d92c3efae8
King, E.
915d0fc4-38c4-4892-a44e-03c3104fcd9a
Nicoll, J.A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Budge, M.M.
8c6e98e2-06d7-4a9b-9cf9-b732e775a665
de Jager, C.A.
3f05f146-0052-4e06-998c-08a5e5ca8dbe
Hogervorst, E.
92fbaaf8-147e-414f-b501-0184acd378fa
Esiri, M.M.
6f03b440-26e8-42ca-8357-2a2a90f23b94
Ragoussis, J.
573f62c8-db06-403a-9e5f-8e725008a7f3
Smith, A.D.
5f9e0088-dded-4e42-9106-32c97dbcc964
Lehmann, D.J.
25e73037-b0dc-4dbb-85ff-ba4fcb90637a
Butler, H.T.
6ba68674-c45f-4920-838b-774ca6601cfa
Warden, D.R.
d360fee1-0842-48f3-8f0c-b43826cea589
Combrinck, M.
b1a6ab1b-dc44-4aaa-9c71-34d92c3efae8
King, E.
915d0fc4-38c4-4892-a44e-03c3104fcd9a
Nicoll, J.A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Budge, M.M.
8c6e98e2-06d7-4a9b-9cf9-b732e775a665
de Jager, C.A.
3f05f146-0052-4e06-998c-08a5e5ca8dbe
Hogervorst, E.
92fbaaf8-147e-414f-b501-0184acd378fa
Esiri, M.M.
6f03b440-26e8-42ca-8357-2a2a90f23b94
Ragoussis, J.
573f62c8-db06-403a-9e5f-8e725008a7f3
Smith, A.D.
5f9e0088-dded-4e42-9106-32c97dbcc964

Lehmann, D.J., Butler, H.T., Warden, D.R., Combrinck, M., King, E., Nicoll, J.A.R., Budge, M.M., de Jager, C.A., Hogervorst, E., Esiri, M.M., Ragoussis, J. and Smith, A.D. (2003) Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men. Neuroscience Letters, 340 (2), 87-90. (doi:10.1016/S0304-3940(03)00069-7). (PMID:12668243)

Record type: Article

Abstract

We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (< or = 20 CAG repeats) were associated with AD (adjusted odds ratio = 2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (< 65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.

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More information

e-pub ahead of print date: 15 March 2003
Published date: 10 April 2003
Keywords: sex steroids, estrogen, testosterone, neuroprotection, gender, x chromosome, apolipoprotein e 4, butyrylcholinesterase k variant

Identifiers

Local EPrints ID: 27637
URI: http://eprints.soton.ac.uk/id/eprint/27637
ISSN: 0304-3940
PURE UUID: bbce2986-c486-4ef0-adc1-48dcb8b16791
ORCID for J.A.R. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 27 Apr 2006
Last modified: 09 Jan 2022 03:09

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Contributors

Author: D.J. Lehmann
Author: H.T. Butler
Author: D.R. Warden
Author: M. Combrinck
Author: E. King
Author: J.A.R. Nicoll ORCID iD
Author: M.M. Budge
Author: C.A. de Jager
Author: E. Hogervorst
Author: M.M. Esiri
Author: J. Ragoussis
Author: A.D. Smith

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