Genetic variation of the APOE promoter and outcome after head injury
Genetic variation of the APOE promoter and outcome after head injury
The APOE-4 allele is associated with risk for Alzheimer’s disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors’ data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.
683-685
Lendon, C. L.
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Harris, J.M.
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Pritchard, A.L.
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Nicoll, J.A.
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Teasdale, G.M.
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Murray, G.
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2003
Lendon, C. L.
55425f30-b294-4901-8b45-72be701fce61
Harris, J.M.
112534fb-2b02-446f-88fc-3e78358655d7
Pritchard, A.L.
a00aea6f-f89a-4eef-8686-6dfd8aac0a9a
Nicoll, J.A.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Teasdale, G.M.
d21802fd-3466-438b-85dd-b1c859201a7e
Murray, G.
b4f056f8-567f-4133-a1a3-85339df92a7c
Lendon, C. L., Harris, J.M., Pritchard, A.L., Nicoll, J.A., Teasdale, G.M. and Murray, G.
(2003)
Genetic variation of the APOE promoter and outcome after head injury.
Neurology, 61 (5), .
Abstract
The APOE-4 allele is associated with risk for Alzheimer’s disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors’ data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.
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Published date: 2003
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Local EPrints ID: 27638
URI: http://eprints.soton.ac.uk/id/eprint/27638
ISSN: 0028-3878
PURE UUID: 3222c503-ebdd-4089-9327-bbfa47519ab6
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Date deposited: 27 Apr 2006
Last modified: 09 Jan 2022 03:09
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Contributors
Author:
C. L. Lendon
Author:
J.M. Harris
Author:
A.L. Pritchard
Author:
G.M. Teasdale
Author:
G. Murray
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