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Genetic variation of the APOE promoter and outcome after head injury

Lendon, C. L., Harris, J.M., Pritchard, A.L., Nicoll, J.A., Teasdale, G.M. and Murray, G. (2003) Genetic variation of the APOE promoter and outcome after head injury Neurology, 61, (5), pp. 683-685.

Record type: Article


The APOE-4 allele is associated with risk for Alzheimer’s disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors’ data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.

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Published date: 2003


Local EPrints ID: 27638
ISSN: 0028-3878
PURE UUID: 3222c503-ebdd-4089-9327-bbfa47519ab6
ORCID for J.A. Nicoll: ORCID iD

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Date deposited: 27 Apr 2006
Last modified: 17 Jul 2017 16:04

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Author: C. L. Lendon
Author: J.M. Harris
Author: A.L. Pritchard
Author: J.A. Nicoll ORCID iD
Author: G.M. Teasdale
Author: G. Murray

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