The University of Southampton
University of Southampton Institutional Repository

APOE and cerebral amyloid angiopathy in the elderly

Love, Seth, Nicoll, James A.R., Hughes, Anthony and Wilcock, Gordon K. (2003) APOE and cerebral amyloid angiopathy in the elderly Neuroreport, 14, (11), pp. 1535-1536.

Record type: Article


Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE [varepsilon]4 is associated with increased prevalence and severity of CAA in Alzheimer's disease (AD) and in cerebral haemorrhage. We examined CAA in relation to APOE genotype in brains from 152 people aged 60-102 years, without AD or cerebral haemorrhage. Prevalence of CAA increased with age (p = 0.003). CAA was not associated with APOE genotype. The frequency of [varepsilon]4 showed a significant negative association with age (p = 0.016). Age at death was significantly lower in those with than without [varepsilon]4 (p = 0.028). Possession of [varepsilon]4 does not by itself confer an increased risk of CAA but may be associated with reduced longevity even in the absence of AD or cerebral haemorrhage.

Full text not available from this repository.

More information

Published date: 2003


Local EPrints ID: 27642
PURE UUID: 17b38330-dd0a-40f6-8c7c-718ed7cd201c
ORCID for James A.R. Nicoll: ORCID iD

Catalogue record

Date deposited: 28 Apr 2006
Last modified: 17 Jul 2017 16:04

Export record


Author: Seth Love
Author: Anthony Hughes
Author: Gordon K. Wilcock

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.