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APOE and cerebral amyloid angiopathy in the elderly

Record type: Article

Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE [varepsilon]4 is associated with increased prevalence and severity of CAA in Alzheimer's disease (AD) and in cerebral haemorrhage. We examined CAA in relation to APOE genotype in brains from 152 people aged 60-102 years, without AD or cerebral haemorrhage. Prevalence of CAA increased with age (p = 0.003). CAA was not associated with APOE genotype. The frequency of [varepsilon]4 showed a significant negative association with age (p = 0.016). Age at death was significantly lower in those with than without [varepsilon]4 (p = 0.028). Possession of [varepsilon]4 does not by itself confer an increased risk of CAA but may be associated with reduced longevity even in the absence of AD or cerebral haemorrhage.

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Citation

Love, Seth, Nicoll, James A.R., Hughes, Anthony and Wilcock, Gordon K. (2003) APOE and cerebral amyloid angiopathy in the elderly Neuroreport, 14, (11), pp. 1535-1536.

More information

Published date: 2003

Identifiers

Local EPrints ID: 27642
URI: http://eprints.soton.ac.uk/id/eprint/27642
PURE UUID: 17b38330-dd0a-40f6-8c7c-718ed7cd201c
ORCID for James A.R. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 28 Apr 2006
Last modified: 17 Jul 2017 16:04

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Contributors

Author: Seth Love
Author: Anthony Hughes
Author: Gordon K. Wilcock

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