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Use of St John's wort (Hypericum perforatum L) in members of a depression self-help organisation: a 12-week open prospective pilot study using the HADS scale

Use of St John's wort (Hypericum perforatum L) in members of a depression self-help organisation: a 12-week open prospective pilot study using the HADS scale
Use of St John's wort (Hypericum perforatum L) in members of a depression self-help organisation: a 12-week open prospective pilot study using the HADS scale
The findings of randomised controlled trials confirm that St John's wort (Hypericum perforatum L) is effective in reducing symptoms in mild to moderate depression, but few studies have focused on the effect on anxiety symptoms. Most studies have employed observer-rated scales to measure treatment outcome, only few used self-rated scales. We sought to examine these issues in a cohort of members of the depression self-help organisation Depression Alliance UK (n= 39). Hospital Anxiety and Depression (HADS) scales were used at baseline, prior to St John's wort administration, and for subsequent assessments at weeks 4, 8 and 12. A subject-rated version of the Clinical Global Impression – Improvement (CGI-I) scale was employed at follow-up assessments. HADS scores were significantly reduced after taking St John's wort, particularly for those reporting milder depression and more severe anxiety. HADS scores compared well with patient improvement ratings, indicating the feasibility of use in this population. Controlled studies are needed in a larger cohort to examine these findings, before definitive conclusions can be made.
st. john's wort, hypericum, depression, anxiety, hads
1355-2570
15-20
Mayers, A.G.
e095a5b1-c9e2-44d2-baf1-1f1403e954ce
Baldwin, D.S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Dyson, R.
e3f59039-9209-4396-8af8-6c0fe0a8a7fb
Middleton, R.W.
5c215bda-8bf8-40a3-86f0-c9462b8e59d9
Mustapha, A.
b37074a7-9d90-437c-958b-b6cac87547e0
Mayers, A.G.
e095a5b1-c9e2-44d2-baf1-1f1403e954ce
Baldwin, D.S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Dyson, R.
e3f59039-9209-4396-8af8-6c0fe0a8a7fb
Middleton, R.W.
5c215bda-8bf8-40a3-86f0-c9462b8e59d9
Mustapha, A.
b37074a7-9d90-437c-958b-b6cac87547e0

Mayers, A.G., Baldwin, D.S., Dyson, R., Middleton, R.W. and Mustapha, A. (2003) Use of St John's wort (Hypericum perforatum L) in members of a depression self-help organisation: a 12-week open prospective pilot study using the HADS scale. Primary Care Psychiatry, 9 (1), 15-20. (doi:10.1185/135525703125002342).

Record type: Article

Abstract

The findings of randomised controlled trials confirm that St John's wort (Hypericum perforatum L) is effective in reducing symptoms in mild to moderate depression, but few studies have focused on the effect on anxiety symptoms. Most studies have employed observer-rated scales to measure treatment outcome, only few used self-rated scales. We sought to examine these issues in a cohort of members of the depression self-help organisation Depression Alliance UK (n= 39). Hospital Anxiety and Depression (HADS) scales were used at baseline, prior to St John's wort administration, and for subsequent assessments at weeks 4, 8 and 12. A subject-rated version of the Clinical Global Impression – Improvement (CGI-I) scale was employed at follow-up assessments. HADS scores were significantly reduced after taking St John's wort, particularly for those reporting milder depression and more severe anxiety. HADS scores compared well with patient improvement ratings, indicating the feasibility of use in this population. Controlled studies are needed in a larger cohort to examine these findings, before definitive conclusions can be made.

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More information

Published date: 2003
Keywords: st. john's wort, hypericum, depression, anxiety, hads

Identifiers

Local EPrints ID: 27649
URI: http://eprints.soton.ac.uk/id/eprint/27649
ISSN: 1355-2570
PURE UUID: 30938ce5-dd94-4501-8cb5-d6457a3e660e
ORCID for D.S. Baldwin: ORCID iD orcid.org/0000-0003-3343-0907

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 09 Jan 2022 02:48

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Contributors

Author: A.G. Mayers
Author: D.S. Baldwin ORCID iD
Author: R. Dyson
Author: R.W. Middleton
Author: A. Mustapha

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