McCarron, M.O., Weir, C.J., Muir, K.W., Hoffmann, K.L., Graffagnino, C., Nicoll, J.A., Lees, K.R. and Alberts, M.J.
Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage
Acta Neurologica Scandinavica, 107, (2), . (doi:10.1034/j.1600-0404.2003.01365.x).
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Objective: to determine the relationship between the apolipoprotein E (APOE) ?4 allele and in-hospital mortality from intracerebral haemorrhage (ICH).
Material and methods: patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients.
Results: there were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE?4 allele (P = 0.026) significantly reduced in-hospital survival.
Conclusion: the APOE?4 allele in this population may be associated with poor survival following ICH.
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