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Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

McCarron, M.O., Weir, C.J., Muir, K.W., Hoffmann, K.L., Graffagnino, C., Nicoll, J.A., Lees, K.R. and Alberts, M.J. (2003) Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage Acta Neurologica Scandinavica, 107, (2), pp. 106-109. (doi:10.1034/j.1600-0404.2003.01365.x).

Record type: Article


Objective: to determine the relationship between the apolipoprotein E (APOE) ?4 allele and in-hospital mortality from intracerebral haemorrhage (ICH).
Material and methods: patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients.
Results: there were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE?4 allele (P = 0.026) significantly reduced in-hospital survival.
Conclusion: the APOE?4 allele in this population may be associated with poor survival following ICH.

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Published date: 2003


Local EPrints ID: 27652
PURE UUID: eea06305-f76c-471c-ba2d-3a5f7f29ed12
ORCID for J.A. Nicoll: ORCID iD

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Date deposited: 28 Apr 2006
Last modified: 17 Jul 2017 16:04

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Author: M.O. McCarron
Author: C.J. Weir
Author: K.W. Muir
Author: K.L. Hoffmann
Author: C. Graffagnino
Author: J.A. Nicoll ORCID iD
Author: K.R. Lees
Author: M.J. Alberts

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