Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage
Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage
Objective: to determine the relationship between the apolipoprotein E (APOE) ?4 allele and in-hospital mortality from intracerebral haemorrhage (ICH).
Material and methods: patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients.
Results: there were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE?4 allele (P = 0.026) significantly reduced in-hospital survival.
Conclusion: the APOE?4 allele in this population may be associated with poor survival following ICH.
106-109
McCarron, M.O.
49985d16-f2e0-4d44-aad0-2591fcbeb4c3
Weir, C.J.
c3d2c5ad-6881-40bc-b36c-88afaa438e00
Muir, K.W.
a3a4bfa8-60a6-4ed3-9a7e-4619256f3c4f
Hoffmann, K.L.
89912cf0-1ecf-4d0c-bac9-0160010cec0a
Graffagnino, C.
a4aa500c-ec9c-4d43-9818-a8fc6a11d1d5
Nicoll, J.A.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Lees, K.R.
29f45d51-fc58-4f1a-9c16-a31950868daf
Alberts, M.J.
9ce9c1e1-8f22-4fc7-b930-b48a03f5e9cb
2003
McCarron, M.O.
49985d16-f2e0-4d44-aad0-2591fcbeb4c3
Weir, C.J.
c3d2c5ad-6881-40bc-b36c-88afaa438e00
Muir, K.W.
a3a4bfa8-60a6-4ed3-9a7e-4619256f3c4f
Hoffmann, K.L.
89912cf0-1ecf-4d0c-bac9-0160010cec0a
Graffagnino, C.
a4aa500c-ec9c-4d43-9818-a8fc6a11d1d5
Nicoll, J.A.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Lees, K.R.
29f45d51-fc58-4f1a-9c16-a31950868daf
Alberts, M.J.
9ce9c1e1-8f22-4fc7-b930-b48a03f5e9cb
McCarron, M.O., Weir, C.J., Muir, K.W., Hoffmann, K.L., Graffagnino, C., Nicoll, J.A., Lees, K.R. and Alberts, M.J.
(2003)
Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage.
Acta Neurologica Scandinavica, 107 (2), .
(doi:10.1034/j.1600-0404.2003.01365.x).
Abstract
Objective: to determine the relationship between the apolipoprotein E (APOE) ?4 allele and in-hospital mortality from intracerebral haemorrhage (ICH).
Material and methods: patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients.
Results: there were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE?4 allele (P = 0.026) significantly reduced in-hospital survival.
Conclusion: the APOE?4 allele in this population may be associated with poor survival following ICH.
This record has no associated files available for download.
More information
Published date: 2003
Identifiers
Local EPrints ID: 27652
URI: http://eprints.soton.ac.uk/id/eprint/27652
PURE UUID: eea06305-f76c-471c-ba2d-3a5f7f29ed12
Catalogue record
Date deposited: 28 Apr 2006
Last modified: 16 Mar 2024 03:26
Export record
Altmetrics
Contributors
Author:
M.O. McCarron
Author:
C.J. Weir
Author:
K.W. Muir
Author:
K.L. Hoffmann
Author:
C. Graffagnino
Author:
K.R. Lees
Author:
M.J. Alberts
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
