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Association between interleukin-1A polymorphism and cerebral amyloid angiopathy-related hemorrhage

Record type: Article

Background and Purpose— It has been suggested that the interleukin-1A (IL-1A) allele 2 is a risk factor for Alzheimer’s disease (AD). Because cerebral amyloid angiopathy–related hemorrhage (CAAH) often coexists with AD, we examined the IL-1A polymorphism in CAAH.
Methods— In a case-control study, patients with pathologically verified CAAH, AD patients without intracerebral hemorrhage, and neuropathologically normal control subjects were studied. DNA was extracted from brain tissue, and IL-1A was genotyped. Logistic regression was used to examine the IL-1A polymorphism in CAAH patients with and without AD compared with AD and non-AD control subjects.
Results— There were 42 patients with CAAH, 232 AD patients, and 167 non-AD control subjects. In age-adjusted analyses, there was no association between possession of IL-1A allele 2 and risk of CAAH compared with AD control subjects (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.45 to 1.97; P=0.87) or non-AD control subjects (OR, 0.94; 95% CI, 0.47 to 1.87; P=0.86). Stratifying for the presence of apolipoprotein E 2 or 4 demonstrated the known increased risk of CAAH from these lipoprotein E alleles. Subgroup analyses demonstrated a nonsignificant excess of the IL-1A 2,2 genotype in patients with CAAH and AD compared with those CAAH patients who did not have histological evidence indicating AD (OR, 2.17; 95% CI, 0.15 to 122.3; P=0.64). Comparisons between CAAH patients with AD and AD control subjects and between CAAH patients without AD and non-AD control subjects did not demonstrate an association between CAAH and possession of either the IL-1A allele 2 or the 2,2 genotype.
Conclusions— The IL-1A allele 2 or 2,2 genotype does not appear to be a major risk factor for CAAH.

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Citation

McCarron, M.O., Stewart, J., McCarron, P., Love, S., Vinters, H.V., Ironside, J.W., Mann, D.M., Graham, D.I. and Nicoll, J.A. (2003) Association between interleukin-1A polymorphism and cerebral amyloid angiopathy-related hemorrhage Stroke, 34, (10), e193-e195.

More information

Published date: 2003
Keywords: cerebral amyloid angiopathy, interleukins, intracerebral hemorrhage

Identifiers

Local EPrints ID: 27653
URI: http://eprints.soton.ac.uk/id/eprint/27653
ISSN: 0039-2499
PURE UUID: 63c510d1-2188-4923-bd79-09ae1526c15a
ORCID for J.A. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 27 Apr 2006
Last modified: 17 Jul 2017 16:04

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Contributors

Author: M.O. McCarron
Author: J. Stewart
Author: P. McCarron
Author: S. Love
Author: H.V. Vinters
Author: J.W. Ironside
Author: D.M. Mann
Author: D.I. Graham
Author: J.A. Nicoll ORCID iD

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