Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease
Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease
Depressive symptoms have been associated with raised interleukin 1-? (IL-1 ?) plasma levels. The presence of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease, including depressive symptoms, have been shown to be influenced by common genetic polymorphisms. A common polymorphism in the promoter region of IL-1 ? has been linked to altered synthesis of IL-1 ?. We hypothesize that this common genetic polymorphism is a risk factor for the appearance of depressive symptoms in AD. A total of 133 subjects, diagnosed as probable AD and 156 controls were genotyped for the -511 variant of IL-1. Neither genotype or allele frequencies differed between the AD and control group. However, an allelic association was found between the T variant and the symptoms of depression in AD subjects. Genotypic analysis showed that heterozygotes were three times more likely to develop depressive symptoms than CC homozygotes.
alzheimers disease, interleukin 1-?, IL1?, depression, heterosis
50-53
McCulley, Michelle C.
bd26d469-a0ce-48e1-80ea-277bd689d710
Day, Ian N.M.
b749b30a-1f4c-40eb-af0e-a50427388b39
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
2004
McCulley, Michelle C.
bd26d469-a0ce-48e1-80ea-277bd689d710
Day, Ian N.M.
b749b30a-1f4c-40eb-af0e-a50427388b39
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
McCulley, Michelle C., Day, Ian N.M. and Holmes, Clive
(2004)
Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease.
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 124 (1), .
(doi:10.1002/ajmg.b.20086).
Abstract
Depressive symptoms have been associated with raised interleukin 1-? (IL-1 ?) plasma levels. The presence of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease, including depressive symptoms, have been shown to be influenced by common genetic polymorphisms. A common polymorphism in the promoter region of IL-1 ? has been linked to altered synthesis of IL-1 ?. We hypothesize that this common genetic polymorphism is a risk factor for the appearance of depressive symptoms in AD. A total of 133 subjects, diagnosed as probable AD and 156 controls were genotyped for the -511 variant of IL-1. Neither genotype or allele frequencies differed between the AD and control group. However, an allelic association was found between the T variant and the symptoms of depression in AD subjects. Genotypic analysis showed that heterozygotes were three times more likely to develop depressive symptoms than CC homozygotes.
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Published date: 2004
Keywords:
alzheimers disease, interleukin 1-?, IL1?, depression, heterosis
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Local EPrints ID: 27655
URI: http://eprints.soton.ac.uk/id/eprint/27655
PURE UUID: bfe83ae5-08a0-4405-a993-0b2931338af9
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Date deposited: 26 Apr 2006
Last modified: 16 Mar 2024 03:06
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Author:
Michelle C. McCulley
Author:
Ian N.M. Day
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