Interleukin-1? exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures
Interleukin-1? exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures
Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotective in models of combined oxygen/glucose deprivation and N-methyl-D-aspartate toxicity, but no potentiation was observed at low IL-1 concentrations. Both protective and toxic effects of IL-1 were fully antagonized by IL-1 receptor antagonist. These data demonstrate that the effects of IL-1 on neuronal injury are complex, and may be directly related to the injury paradigm studied.
ischaemia, slice culture, hippocampus, excitotoxicity, cytokine, Interleukin-1?
29-32
Pringle, Ashley K.
6339ed95-c491-43a8-b2fb-2384466dc80d
Niyadurupola, Nuwan
c9f7dc65-6972-43d7-801c-ee9f3eb37449
Johns, Paul
0e68c77b-830c-4eda-aaba-7ff09280d5e6
Anthony, Daniel C.
928249fa-dcf4-4088-b95b-ce14c719164d
Iannotti, Fausto
b7772bb7-d09c-4aca-8c5c-96e8da023c00
2001
Pringle, Ashley K.
6339ed95-c491-43a8-b2fb-2384466dc80d
Niyadurupola, Nuwan
c9f7dc65-6972-43d7-801c-ee9f3eb37449
Johns, Paul
0e68c77b-830c-4eda-aaba-7ff09280d5e6
Anthony, Daniel C.
928249fa-dcf4-4088-b95b-ce14c719164d
Iannotti, Fausto
b7772bb7-d09c-4aca-8c5c-96e8da023c00
Pringle, Ashley K., Niyadurupola, Nuwan, Johns, Paul, Anthony, Daniel C. and Iannotti, Fausto
(2001)
Interleukin-1? exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures.
Neuroscience Letters, 305 (1), .
(doi:10.1016/S0304-3940(01)01795-5).
Abstract
Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotective in models of combined oxygen/glucose deprivation and N-methyl-D-aspartate toxicity, but no potentiation was observed at low IL-1 concentrations. Both protective and toxic effects of IL-1 were fully antagonized by IL-1 receptor antagonist. These data demonstrate that the effects of IL-1 on neuronal injury are complex, and may be directly related to the injury paradigm studied.
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Published date: 2001
Keywords:
ischaemia, slice culture, hippocampus, excitotoxicity, cytokine, Interleukin-1?
Identifiers
Local EPrints ID: 27689
URI: http://eprints.soton.ac.uk/id/eprint/27689
ISSN: 0304-3940
PURE UUID: 8b706131-985b-4ec0-a136-2cc349354091
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Date deposited: 27 Apr 2006
Last modified: 16 Mar 2024 02:48
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Contributors
Author:
Nuwan Niyadurupola
Author:
Paul Johns
Author:
Daniel C. Anthony
Author:
Fausto Iannotti
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