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Interleukin-1? exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures

Record type: Article

Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotective in models of combined oxygen/glucose deprivation and N-methyl-D-aspartate toxicity, but no potentiation was observed at low IL-1 concentrations. Both protective and toxic effects of IL-1 were fully antagonized by IL-1 receptor antagonist. These data demonstrate that the effects of IL-1 on neuronal injury are complex, and may be directly related to the injury paradigm studied.

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Citation

Pringle, Ashley K., Niyadurupola, Nuwan, Johns, Paul, Anthony, Daniel C. and Iannotti, Fausto (2001) Interleukin-1? exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures Neuroscience Letters, 305, (1), pp. 29-32. (doi:10.1016/S0304-3940(01)01795-5).

More information

Published date: 2001
Keywords: ischaemia, slice culture, hippocampus, excitotoxicity, cytokine, Interleukin-1?

Identifiers

Local EPrints ID: 27689
URI: http://eprints.soton.ac.uk/id/eprint/27689
ISSN: 0304-3940
PURE UUID: 8b706131-985b-4ec0-a136-2cc349354091
ORCID for Ashley K. Pringle: ORCID iD orcid.org/0000-0003-2421-4380

Catalogue record

Date deposited: 27 Apr 2006
Last modified: 17 Jul 2017 16:04

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Contributors

Author: Nuwan Niyadurupola
Author: Paul Johns
Author: Daniel C. Anthony
Author: Fausto Iannotti

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