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Apolipoprotein E genotypes and clinical outcome in Guillain-Barré syndrome

Record type: Article

Background: polymorphism of the gene encoding the cholesterol transport protein apolipoprotein E (APOE, gene; apoE, protein), known to be involved in axonal regeneration and remyelination, influences outcome after a variety of central nervous system disorders. Apolipoprotein E gene polymorphisms could affect recovery from Guillain-Barré syndrome.
Objective: to correlate APOE genotypes with residual disability and degree of improvement in Guillain-Barré syndrome, assessed one year after presentation
Methods: 91 patients with the syndrome were recruited from southeast England and their APOE genotypes were determined.
Results: there were no clear differences in APOE genotype or allele frequencies when comparing the 91 patients with controls, nor when comparing 81 patients with good outcome and 10 with poor outcome.
Conclusions: APOE genotype did not influence susceptibility to Guillain-Barré syndrome or recovery from it. This may be because our sample size of 91 was not sufficiently large to detect small differences in recovery associated with different APOE genotypes, or because cholesterol transportation is not a crucial rate limiting step in peripheral nerve regeneration.

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Citation

Pritchard, J., Hughes, R.A.C., Rees, J.H., Willison, H.J. and Nicoll, J.A.R. (2003) Apolipoprotein E genotypes and clinical outcome in Guillain-Barré syndrome Journal of Neurology, Neurosurgery and Psychiatry, 74, (7), pp. 971-973.

More information

Published date: 2003
Keywords: apolipoprotein E, Guillain-Barré syndrome, neuropathy

Identifiers

Local EPrints ID: 27697
URI: http://eprints.soton.ac.uk/id/eprint/27697
ISSN: 1468-330X
PURE UUID: cebe74dd-3025-4641-94e7-e8ba462288fb
ORCID for J.A.R. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 28 Apr 2006
Last modified: 17 Jul 2017 16:04

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Contributors

Author: J. Pritchard
Author: R.A.C. Hughes
Author: J.H. Rees
Author: H.J. Willison
Author: J.A.R. Nicoll ORCID iD

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