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Dopamine D4 receptor exon III genotype influence on the auditory evoked novelty P3

Dopamine D4 receptor exon III genotype influence on the auditory evoked novelty P3
Dopamine D4 receptor exon III genotype influence on the auditory evoked novelty P3
The functional implications of the dopamine D4 receptor gene (DRD4) exon III polymorphism and its role in the modulation of temperament and in the pathophysiology of psychiatric disorders are still a matter of debate. Based on evidence from animal studies, we hypothesised that this polymorphism is involved in the modulation of the cortical response to novelty as reflected by the auditory evoked novelty P3 event-related potential. In a sample of 46 healthy volunteers, we observed an interactive effect of DRD4 exon III genotype and the eye-blink rate, a measure of central dopaminergic activity, on the novelty P3. These findings suggest that the DRD4 exon III polymorphism influences the processing of novelty and that this influence depends on tonic dopaminergic activity.
2411-2415
Strobel, Alexander
272b7bac-eae5-4649-9a2d-51416f75275a
Debener, Stefan
e6bf9143-09a8-45c0-8536-3564885375d4
Anacker, Kristin
cbd23f98-a2d6-4a78-b23a-74b95fa352c7
Muller, Johannes
cc828a4f-4324-4972-af39-814f2160d651
Lesch, Klaus-Peter
db534daf-4bb9-4915-9f82-b7f194b3cd3c
Brocke, Burkhard
60fbd65b-62d6-4eb0-ba6f-dd2b7148ef9c
Strobel, Alexander
272b7bac-eae5-4649-9a2d-51416f75275a
Debener, Stefan
e6bf9143-09a8-45c0-8536-3564885375d4
Anacker, Kristin
cbd23f98-a2d6-4a78-b23a-74b95fa352c7
Muller, Johannes
cc828a4f-4324-4972-af39-814f2160d651
Lesch, Klaus-Peter
db534daf-4bb9-4915-9f82-b7f194b3cd3c
Brocke, Burkhard
60fbd65b-62d6-4eb0-ba6f-dd2b7148ef9c

Strobel, Alexander, Debener, Stefan, Anacker, Kristin, Muller, Johannes, Lesch, Klaus-Peter and Brocke, Burkhard (2004) Dopamine D4 receptor exon III genotype influence on the auditory evoked novelty P3. NeuroReport, 15 (15), 2411-2415.

Record type: Article

Abstract

The functional implications of the dopamine D4 receptor gene (DRD4) exon III polymorphism and its role in the modulation of temperament and in the pathophysiology of psychiatric disorders are still a matter of debate. Based on evidence from animal studies, we hypothesised that this polymorphism is involved in the modulation of the cortical response to novelty as reflected by the auditory evoked novelty P3 event-related potential. In a sample of 46 healthy volunteers, we observed an interactive effect of DRD4 exon III genotype and the eye-blink rate, a measure of central dopaminergic activity, on the novelty P3. These findings suggest that the DRD4 exon III polymorphism influences the processing of novelty and that this influence depends on tonic dopaminergic activity.

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Published date: 2004

Identifiers

Local EPrints ID: 27721
URI: http://eprints.soton.ac.uk/id/eprint/27721
PURE UUID: d361f411-2d25-4a86-8c1a-ef0f401e3d13

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Date deposited: 27 Apr 2006
Last modified: 08 Jan 2022 12:55

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Contributors

Author: Alexander Strobel
Author: Stefan Debener
Author: Kristin Anacker
Author: Johannes Muller
Author: Klaus-Peter Lesch
Author: Burkhard Brocke

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