The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Failure to find DUP25 in patients with anxiety disorders, in control individuals, or in previously reported positive control cell lines

Failure to find DUP25 in patients with anxiety disorders, in control individuals, or in previously reported positive control cell lines
Failure to find DUP25 in patients with anxiety disorders, in control individuals, or in previously reported positive control cell lines
Investigation of the co-occurrence of panic and phobic disorders with joint laxity led to the identification of various forms of interstitial duplications involving human chromosome 15q24-q26 (named "DUP25") in a Spanish population. DUP25 was observed in 68 of 70 (97%) patients assigned the diagnosis panic disorder/agoraphobia. DUP25 was also found in 14 of 189 (7%) control individuals. In the present study, we replicated the experimental conditions described by Gratacòs and colleagues in which fluorescence in situ hybridization was used to examine metaphase chromosomes of patients with panic disorder/social phobia and of control individuals from a southern region of the United Kingdom, the primary aim being to determine the prevalence of this chromosomal rearrangement in a geographically and ethnically distinct population. DUP25 was not observed in any of our 16 patients or 40 control samples or in three previously reported DUP25-positive control (Centre d'Etude du Polymorphisme Humain) cell lines, indicating a highly significant difference in the frequency of DUP25 between the study by Gratacòs and colleagues and the present investigation.
0002-9297
535-538
Tabiner, Melody
1c6d7fd3-2d51-499c-ac10-88e44e498e4d
Youings, Sheila
bedc8b85-684a-44ba-b47a-9e74fb566ede
Dennis, Nicholas
154aa617-52e2-4711-98ef-89fef8610de7
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Buis, Christel
23acb3e3-621a-4bd2-b5c4-947a127a9ded
Mayers, Andrew
7d4e05b2-14ab-4386-9edf-942d0455ec39
Jacobs, Patricia A.
d87ec15b-13c3-4868-96f1-b4b99030fa5b
Crolla, John A.
c5f23751-8de9-4a55-9cc5-ca2fb635769c
Tabiner, Melody
1c6d7fd3-2d51-499c-ac10-88e44e498e4d
Youings, Sheila
bedc8b85-684a-44ba-b47a-9e74fb566ede
Dennis, Nicholas
154aa617-52e2-4711-98ef-89fef8610de7
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Buis, Christel
23acb3e3-621a-4bd2-b5c4-947a127a9ded
Mayers, Andrew
7d4e05b2-14ab-4386-9edf-942d0455ec39
Jacobs, Patricia A.
d87ec15b-13c3-4868-96f1-b4b99030fa5b
Crolla, John A.
c5f23751-8de9-4a55-9cc5-ca2fb635769c

Tabiner, Melody, Youings, Sheila, Dennis, Nicholas, Baldwin, David, Buis, Christel, Mayers, Andrew, Jacobs, Patricia A. and Crolla, John A. (2003) Failure to find DUP25 in patients with anxiety disorders, in control individuals, or in previously reported positive control cell lines. American Journal of Human Genetics, 72 (3), 535-538. (doi:10.1086/367777).

Record type: Article

Abstract

Investigation of the co-occurrence of panic and phobic disorders with joint laxity led to the identification of various forms of interstitial duplications involving human chromosome 15q24-q26 (named "DUP25") in a Spanish population. DUP25 was observed in 68 of 70 (97%) patients assigned the diagnosis panic disorder/agoraphobia. DUP25 was also found in 14 of 189 (7%) control individuals. In the present study, we replicated the experimental conditions described by Gratacòs and colleagues in which fluorescence in situ hybridization was used to examine metaphase chromosomes of patients with panic disorder/social phobia and of control individuals from a southern region of the United Kingdom, the primary aim being to determine the prevalence of this chromosomal rearrangement in a geographically and ethnically distinct population. DUP25 was not observed in any of our 16 patients or 40 control samples or in three previously reported DUP25-positive control (Centre d'Etude du Polymorphisme Humain) cell lines, indicating a highly significant difference in the frequency of DUP25 between the study by Gratacòs and colleagues and the present investigation.

Text
024545.web.pdf - Version of Record
Restricted to Repository staff only
Request a copy

More information

Published date: March 2003

Identifiers

Local EPrints ID: 27724
URI: http://eprints.soton.ac.uk/id/eprint/27724
ISSN: 0002-9297
PURE UUID: 5e7be23f-86da-412e-92ba-89c85253747f
ORCID for David Baldwin: ORCID iD orcid.org/0000-0003-3343-0907

Catalogue record

Date deposited: 28 Apr 2006
Last modified: 08 Jan 2022 02:41

Export record

Altmetrics

Contributors

Author: Melody Tabiner
Author: Sheila Youings
Author: Nicholas Dennis
Author: David Baldwin ORCID iD
Author: Christel Buis
Author: Andrew Mayers
Author: Patricia A. Jacobs
Author: John A. Crolla

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×