The association between APOE ?4, age and outcome after head injury: a prospective cohort study
The association between APOE ?4, age and outcome after head injury: a prospective cohort study
Previous preliminary studies have suggested that possession of the APOE ?4 allele is associated with a poor outcome after head injury. This study was designed to confirm and extend those observations in a larger study with examination of additional variables. We prospectively identified admissions to a Neurosurgical Unit for head injury, collected demographic and clinical data, determined APOE genotypes and obtained follow-up information at 6 months. A total of 1094 subjects were enrolled (age range: 0–93 years, mean 37 years). Outcome was assessed using the Glasgow Outcome Scale. There was no overall association between APOE genotype and outcome, with 36% of APOE ?4 carriers having an unfavourable outcome compared with 33% of non-carriers of APOE ?4. However, there was evidence of an interaction between age and APOE genotype on outcome (P = 0.007) such that possession of APOE ?4 reduced the prospect of a favourable outcome in children and young adults. The influence of APOE genotype in younger patients after head injury can be expressed as, at age <15 years, carriage of APOE ?4 being equivalent to ageing by 25 years. This finding is consistent with experimental data suggesting that the effect of APOE genotype on outcome after head injury may be expressed through the processes of repair and recovery.
head injury, traumatic brain injury, genetics, outcome, apolipoprotein E
2556-2561
Teasdale, G.M.
d21802fd-3466-438b-85dd-b1c859201a7e
Murray, G.D.
2a178914-902b-4b73-84ff-5cece4e2f2e8
Nicoll, J.A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
2005
Teasdale, G.M.
d21802fd-3466-438b-85dd-b1c859201a7e
Murray, G.D.
2a178914-902b-4b73-84ff-5cece4e2f2e8
Nicoll, J.A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Teasdale, G.M., Murray, G.D. and Nicoll, J.A.R.
(2005)
The association between APOE ?4, age and outcome after head injury: a prospective cohort study.
Brain, 128 (11), .
(doi:10.1093/brain/awh595).
Abstract
Previous preliminary studies have suggested that possession of the APOE ?4 allele is associated with a poor outcome after head injury. This study was designed to confirm and extend those observations in a larger study with examination of additional variables. We prospectively identified admissions to a Neurosurgical Unit for head injury, collected demographic and clinical data, determined APOE genotypes and obtained follow-up information at 6 months. A total of 1094 subjects were enrolled (age range: 0–93 years, mean 37 years). Outcome was assessed using the Glasgow Outcome Scale. There was no overall association between APOE genotype and outcome, with 36% of APOE ?4 carriers having an unfavourable outcome compared with 33% of non-carriers of APOE ?4. However, there was evidence of an interaction between age and APOE genotype on outcome (P = 0.007) such that possession of APOE ?4 reduced the prospect of a favourable outcome in children and young adults. The influence of APOE genotype in younger patients after head injury can be expressed as, at age <15 years, carriage of APOE ?4 being equivalent to ageing by 25 years. This finding is consistent with experimental data suggesting that the effect of APOE genotype on outcome after head injury may be expressed through the processes of repair and recovery.
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Published date: 2005
Keywords:
head injury, traumatic brain injury, genetics, outcome, apolipoprotein E
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Local EPrints ID: 27726
URI: http://eprints.soton.ac.uk/id/eprint/27726
ISSN: 0006-8950
PURE UUID: 1d6f0446-8e2b-4d45-b5f8-6456b9b69620
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Date deposited: 27 Apr 2006
Last modified: 16 Mar 2024 03:26
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Author:
G.M. Teasdale
Author:
G.D. Murray
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