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Apolipoprotein E genotype, coagulation, and survival following acute stroke

Weir, C.J., McCarron, M.O., Muir, K.W., Dyker, A.G., Bone, I., Lees, K.R. and Nicoll, J.A. (2001) Apolipoprotein E genotype, coagulation, and survival following acute stroke Neurology, 57, (6), pp. 1097-1100.

Record type: Article


The authors hypothesized that divergent influences of the APOE ?4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, ?4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-?4 carriers. Among 529 ischemic stroke patients, increasing ?4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in ?4-carrying ischemic stroke patients.

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Published date: September 2001


Local EPrints ID: 27737
ISSN: 0028-3878
PURE UUID: 5e963d57-69a1-4717-bd13-606875fc7184
ORCID for J.A. Nicoll: ORCID iD

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Date deposited: 27 Apr 2006
Last modified: 17 Jul 2017 16:03

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Author: C.J. Weir
Author: M.O. McCarron
Author: K.W. Muir
Author: A.G. Dyker
Author: I. Bone
Author: K.R. Lees
Author: J.A. Nicoll ORCID iD

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