The University of Southampton
University of Southampton Institutional Repository

Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain

Record type: Article

Cerebral amyloid angiopathy (CAA) is a feature of ageing and Alzheimer's disease (AD); it is also associated with intracerebral hemorrhage and stroke. Here, the pathogenesis of CAA and its effects on the brain are reviewed and the possible effects of CAA on therapies for Alzheimer's disease are evaluated. Tracer experiments in animals and observations on human brains suggest that peptides such as A? are eliminated along the peri-arterial interstitial fluid drainage pathways that are effectively the lymphatics of the brain. In CAA, A? becomes entrapped in drainage pathways in the walls of cerebral arteries, reflecting a failure of elimination of A? from the ageing brain. One consequence of failure in clearance of A? is accumulation of soluble and insoluble A? associated with cognitive decline in AD. Replacement of vascular smooth muscle cells by A? occurs in severe CAA with weakening of artery walls and increased risk of vessel rupture and intracerebral hemorrhage. Risk factors for CAA include mutations of the amyloid precursor protein (APP) gene and possession of the epsi4 allele of apolipoprotein E. There is also evidence that cerebrovascular disease may be a factor in the failure of elimination of Abeta along perivascular pathways in sporadic AD; this would link ageing in cerebral arteries with the pathogenesis of Alzheimer's disease. If therapeutic agents, including anti-Abeta antibodies, are to be used to eliminate A? in the treatment of Alzheimer's disease, the effects of CAA on the treatment and the effects of the treatment on the CAA need to be considered.

Full text not available from this repository.

Citation

Weller, R.O. and Nicoll, J.A. (2003) Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain Neurological Research, 25, (6), pp. 611-616. (doi:10.1179/016164103101202057).

More information

Published date: 2003
Keywords: cerebral amyloid angiopathy, Alzheimer's disease, cerebral hemorrhage, stroke, interstitial fluid, cerbrospinal fluid

Identifiers

Local EPrints ID: 27740
URI: http://eprints.soton.ac.uk/id/eprint/27740
ISSN: 0161-6412
PURE UUID: 369f1068-b228-4fea-9634-c38370d815a1
ORCID for J.A. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 26 Apr 2006
Last modified: 17 Jul 2017 16:03

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×