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Using genetic algorithms to find the most effective stimulus for sensory Neurons.

Using genetic algorithms to find the most effective stimulus for sensory Neurons.
Using genetic algorithms to find the most effective stimulus for sensory Neurons.
Genetic algorithms (GAs) can be used to find maxima in large search spaces in a relatively short period of time. We have used GAs in electrophysiological experiments to find the most effective stimulus (MES) for sensory neurons in the cochlear nucleus and inferior colliculus of anaesthetised guinea pigs. The MES is the stimulus that elicits the greatest number of spikes from a unit.
We show that GAs provide an effective means of determining the best combination of up to four parameters for sinusoids with amplitude modulation. Using GAs, we have found tuning to modulation frequencies as a function of carrier frequency, sound level and temporal asymmetry. These results demonstrate the suitability of GAs in electrophysical experiments for estimating the position of the most effective stimulus in a specified parameter space.
Cochlear nucleus, inferior colliculus, auditory brainstem, amplitude modulation, genetic algorithms, guinea pig, most effective stimulus, temporal asymmetry
0165-0270
73-82
Bleeck, S.
c888ccba-e64c-47bf-b8fa-a687e87ec16c
Patterson, R.D.
78b48520-9b61-4d57-9968-109b51ab39dd
Winter, I.M.
c816c472-68e4-47fb-833d-db8b8d7fde27
Bleeck, S.
c888ccba-e64c-47bf-b8fa-a687e87ec16c
Patterson, R.D.
78b48520-9b61-4d57-9968-109b51ab39dd
Winter, I.M.
c816c472-68e4-47fb-833d-db8b8d7fde27

Bleeck, S., Patterson, R.D. and Winter, I.M. (2003) Using genetic algorithms to find the most effective stimulus for sensory Neurons. Journal of Neuroscience Methods, 125 (1-2), 73-82. (doi:10.1016/S0165-0270(03)00040-2).

Record type: Article

Abstract

Genetic algorithms (GAs) can be used to find maxima in large search spaces in a relatively short period of time. We have used GAs in electrophysiological experiments to find the most effective stimulus (MES) for sensory neurons in the cochlear nucleus and inferior colliculus of anaesthetised guinea pigs. The MES is the stimulus that elicits the greatest number of spikes from a unit.
We show that GAs provide an effective means of determining the best combination of up to four parameters for sinusoids with amplitude modulation. Using GAs, we have found tuning to modulation frequencies as a function of carrier frequency, sound level and temporal asymmetry. These results demonstrate the suitability of GAs in electrophysical experiments for estimating the position of the most effective stimulus in a specified parameter space.

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More information

Published date: 2003
Keywords: Cochlear nucleus, inferior colliculus, auditory brainstem, amplitude modulation, genetic algorithms, guinea pig, most effective stimulus, temporal asymmetry
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 28347
URI: https://eprints.soton.ac.uk/id/eprint/28347
ISSN: 0165-0270
PURE UUID: 41b0b287-9109-47cd-9773-781cc78680eb
ORCID for S. Bleeck: ORCID iD orcid.org/0000-0003-4378-3394

Catalogue record

Date deposited: 02 May 2006
Last modified: 20 Jul 2019 00:55

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