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Broadband attenuation and nonlinear propagation in biological fluids: An experimental facility and measurements

Broadband attenuation and nonlinear propagation in biological fluids: An experimental facility and measurements
Broadband attenuation and nonlinear propagation in biological fluids: An experimental facility and measurements
The design and construction of a versatile experimental facility for making measurements of the frequency-dependence of attenuation coefficient (over the range 1 MHz to 25 MHz) and nonlinear propagation in samples of biological fluids is described. The main feature of the facility is the ability to perform all of the measurements on the same sample of fluid within a short period of time and under temperature control. In particular, the facility allows the axial development of nonlinear waveform distortion to be measured with a wideband bilaminar polyvinylidene difluoride membrane hydrophone to study nonlinear propagation in biological fluids. The system uses a variable length bellows to contain the fluid, with transparent Mylar end-windows to couple the acoustic field into the fluid. Example results for the frequency-dependence of attenuation of Dow Corning 200/350 silicone fluid, used as a standard fluid, are presented and shown to be in good agreement with alternative measurements. Measurements of finite amplitude propagation in amniotic fluid, urine and 4.5% human albumin solutions at physiological temperature (37 °C) are presented and compared with theoretical predictions using existing models. The measurements were made using a 2.25-MHz single-element transducer coupled to a polymethyl methacrylate lens with a focal amplitude gain of 12 in water. The transducer was driven with an eight-cycle tone burst at source pressures up to 0.137 MPa. In general, given an accurate knowledge of the medium parameters and source conditions, the agreement with theoretical prediction is good for the first five harmonics.
experimental facility, broadband attenuation coefficient measurements, nonlinear propagation measurements, biological fluids
0301-5629
1723-33
Verma, P.K.
ee406131-bc2b-48ef-87c9-3156fe587ea9
Humphrey, V.F.
23c9bd0c-7870-428f-b0dd-5ff158d22590
Duck, F.A.
a1178433-533c-4547-8710-3413f044a119
Verma, P.K.
ee406131-bc2b-48ef-87c9-3156fe587ea9
Humphrey, V.F.
23c9bd0c-7870-428f-b0dd-5ff158d22590
Duck, F.A.
a1178433-533c-4547-8710-3413f044a119

Verma, P.K., Humphrey, V.F. and Duck, F.A. (2005) Broadband attenuation and nonlinear propagation in biological fluids: An experimental facility and measurements. Ultrasound in Medicine & Biology, 31 (12), 1723-33. (doi:10.1016/j.ultrasmedbio.2005.08.005).

Record type: Article

Abstract

The design and construction of a versatile experimental facility for making measurements of the frequency-dependence of attenuation coefficient (over the range 1 MHz to 25 MHz) and nonlinear propagation in samples of biological fluids is described. The main feature of the facility is the ability to perform all of the measurements on the same sample of fluid within a short period of time and under temperature control. In particular, the facility allows the axial development of nonlinear waveform distortion to be measured with a wideband bilaminar polyvinylidene difluoride membrane hydrophone to study nonlinear propagation in biological fluids. The system uses a variable length bellows to contain the fluid, with transparent Mylar end-windows to couple the acoustic field into the fluid. Example results for the frequency-dependence of attenuation of Dow Corning 200/350 silicone fluid, used as a standard fluid, are presented and shown to be in good agreement with alternative measurements. Measurements of finite amplitude propagation in amniotic fluid, urine and 4.5% human albumin solutions at physiological temperature (37 °C) are presented and compared with theoretical predictions using existing models. The measurements were made using a 2.25-MHz single-element transducer coupled to a polymethyl methacrylate lens with a focal amplitude gain of 12 in water. The transducer was driven with an eight-cycle tone burst at source pressures up to 0.137 MPa. In general, given an accurate knowledge of the medium parameters and source conditions, the agreement with theoretical prediction is good for the first five harmonics.

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More information

Published date: 2005
Keywords: experimental facility, broadband attenuation coefficient measurements, nonlinear propagation measurements, biological fluids

Identifiers

Local EPrints ID: 28397
URI: https://eprints.soton.ac.uk/id/eprint/28397
ISSN: 0301-5629
PURE UUID: 966dcae0-976d-47b9-a57f-d214261f0984
ORCID for V.F. Humphrey: ORCID iD orcid.org/0000-0002-3580-5373

Catalogue record

Date deposited: 02 May 2006
Last modified: 17 Sep 2019 00:53

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