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The time course of recovery from suppression and facilitation from single units in the mammalian cochlear nucleus

The time course of recovery from suppression and facilitation from single units in the mammalian cochlear nucleus
The time course of recovery from suppression and facilitation from single units in the mammalian cochlear nucleus
The responses to two identical, consecutive pure tone stimuli with varying inter-stimulus intervals (?ts) were measured for 89 neurons in the cochlear nucleus of the anaesthetised guinea pig. We observed two main effects; either a decrease (suppression) or an increase (facilitation) in response to the second tone followed by an exponential recovery. Response behaviour correlated with the unit type; primary-like, primary-like with notch and transient-chopper units showed a recovery from suppression that was very similar to that already reported in the auditory nerve.
For chopper units the strength of the adaptation was correlated with the units regularity of spike discharge; sustained chopper (CS) units showed less suppression than transient choppers. Onset units showed complete suppression at short ?ts. Pause/Build (PB) units responded with increased activity to the second tone. In contrast to previous studies in the cochlear nucleus the recovery from suppression or facilitation was well described by a single exponential function, enabling us to define a recovery time constant and a maximum suppression/facilitation. There appeared to be a hierarchy in the time constant of recovery with PB and CS units showing the longest recovery times and onset units showing the shortest.
adaptation, forward masking, auditory brainstem, onset unit, primary-like, chopper
0378-5955
176-184
Bleeck, Stefan
c888ccba-e64c-47bf-b8fa-a687e87ec16c
Sayles, Mark
4a6d71ab-169a-4d76-a1ac-5251c8716a64
Ingham, Neil J.
30deebff-3b47-40bc-b347-047b51c80fe3
Winter, Ian M.
e169233c-fc00-44fe-a0ac-5fc998095153
Bleeck, Stefan
c888ccba-e64c-47bf-b8fa-a687e87ec16c
Sayles, Mark
4a6d71ab-169a-4d76-a1ac-5251c8716a64
Ingham, Neil J.
30deebff-3b47-40bc-b347-047b51c80fe3
Winter, Ian M.
e169233c-fc00-44fe-a0ac-5fc998095153

Bleeck, Stefan, Sayles, Mark, Ingham, Neil J. and Winter, Ian M. (2006) The time course of recovery from suppression and facilitation from single units in the mammalian cochlear nucleus. Hearing Research, 212 (1-2), 176-184. (doi:10.1016/j.heares.2005.12.005).

Record type: Article

Abstract

The responses to two identical, consecutive pure tone stimuli with varying inter-stimulus intervals (?ts) were measured for 89 neurons in the cochlear nucleus of the anaesthetised guinea pig. We observed two main effects; either a decrease (suppression) or an increase (facilitation) in response to the second tone followed by an exponential recovery. Response behaviour correlated with the unit type; primary-like, primary-like with notch and transient-chopper units showed a recovery from suppression that was very similar to that already reported in the auditory nerve.
For chopper units the strength of the adaptation was correlated with the units regularity of spike discharge; sustained chopper (CS) units showed less suppression than transient choppers. Onset units showed complete suppression at short ?ts. Pause/Build (PB) units responded with increased activity to the second tone. In contrast to previous studies in the cochlear nucleus the recovery from suppression or facilitation was well described by a single exponential function, enabling us to define a recovery time constant and a maximum suppression/facilitation. There appeared to be a hierarchy in the time constant of recovery with PB and CS units showing the longest recovery times and onset units showing the shortest.

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More information

Published date: 2006
Keywords: adaptation, forward masking, auditory brainstem, onset unit, primary-like, chopper
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 28475
URI: https://eprints.soton.ac.uk/id/eprint/28475
ISSN: 0378-5955
PURE UUID: 0726618a-b333-4173-bd6c-8dd394838889
ORCID for Stefan Bleeck: ORCID iD orcid.org/0000-0003-4378-3394

Catalogue record

Date deposited: 03 May 2006
Last modified: 06 Jun 2018 12:41

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