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Risperidone in chronic schizophrenia: a detailed audit, open switch study and two-year follow-up of patients on depot medication

Risperidone in chronic schizophrenia: a detailed audit, open switch study and two-year follow-up of patients on depot medication
Risperidone in chronic schizophrenia: a detailed audit, open switch study and two-year follow-up of patients on depot medication
Little information exists on the medium- to long-term outcome of switching patients with schizophrenia from traditional depot to atypical oral antipsychotic agents. By detailed clinical audit, we identified a representative group of 102 patients of an Irish psychiatric service with DSM-IV chronic schizophrenia and on depot neuroleptics for a mean of 15 years. Of 69 eligible to participate, 33 entered a 6-month switch study of risperidone, with limited follow-up of consenters and non-consenters at 1 and 2 years. At 6 months, 23 of 33 were still on risperidone and had small significant improvements in clinical and extrapyramidal side effects, QOL and adjunct medication measures over baseline. At 12 months, 19 of 33 were still on risperidone, reducing to 13 of 33 at 2 years. At 2 years, of 32 surviving consenters to switch, 19 had suffered clinically detrimental events and were no longer on risperidone, compared to none of the 33 surviving non-consenters, who were all still on depot. These findings suggest that switching from depot to risperidone may encounter high rates of refusal and attrition subsequent to switch. While a majority of switched patients may improve after to least 6 months, audit plus switch may have clinically unfavourable effects on others over a 2-year follow-up period.
Risperidone, schizophrenia, depot, audit, switch study, follow-up
0924-9338
459-465
Conlon, L.
4c253761-ab25-4f30-bd0d-94ba96f8e748
Fahy, T.J.
cf0ba70f-594b-41c0-947a-4d13c537c14a
O'Toole, R.
adc4057a-3b52-4241-aadd-65604f3a17de
Gilligan, J.
5c33d888-06af-4432-8fcd-03506b7be227
Prescott, P.
cf0adfdd-989b-4f15-9e60-ef85eed817b2
Conlon, L.
4c253761-ab25-4f30-bd0d-94ba96f8e748
Fahy, T.J.
cf0ba70f-594b-41c0-947a-4d13c537c14a
O'Toole, R.
adc4057a-3b52-4241-aadd-65604f3a17de
Gilligan, J.
5c33d888-06af-4432-8fcd-03506b7be227
Prescott, P.
cf0adfdd-989b-4f15-9e60-ef85eed817b2

Conlon, L., Fahy, T.J., O'Toole, R., Gilligan, J. and Prescott, P. (2002) Risperidone in chronic schizophrenia: a detailed audit, open switch study and two-year follow-up of patients on depot medication. European Psychiatry, 17 (8), 459-465. (doi:10.1016/S0924-9338(02)00709-5).

Record type: Article

Abstract

Little information exists on the medium- to long-term outcome of switching patients with schizophrenia from traditional depot to atypical oral antipsychotic agents. By detailed clinical audit, we identified a representative group of 102 patients of an Irish psychiatric service with DSM-IV chronic schizophrenia and on depot neuroleptics for a mean of 15 years. Of 69 eligible to participate, 33 entered a 6-month switch study of risperidone, with limited follow-up of consenters and non-consenters at 1 and 2 years. At 6 months, 23 of 33 were still on risperidone and had small significant improvements in clinical and extrapyramidal side effects, QOL and adjunct medication measures over baseline. At 12 months, 19 of 33 were still on risperidone, reducing to 13 of 33 at 2 years. At 2 years, of 32 surviving consenters to switch, 19 had suffered clinically detrimental events and were no longer on risperidone, compared to none of the 33 surviving non-consenters, who were all still on depot. These findings suggest that switching from depot to risperidone may encounter high rates of refusal and attrition subsequent to switch. While a majority of switched patients may improve after to least 6 months, audit plus switch may have clinically unfavourable effects on others over a 2-year follow-up period.

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Published date: 2002
Keywords: Risperidone, schizophrenia, depot, audit, switch study, follow-up
Organisations: Statistics

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Local EPrints ID: 29996
URI: http://eprints.soton.ac.uk/id/eprint/29996
ISSN: 0924-9338
PURE UUID: 1d0e526d-5832-4cf5-93a8-719150a46e9d

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Date deposited: 11 May 2006
Last modified: 15 Jul 2019 19:07

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Contributors

Author: L. Conlon
Author: T.J. Fahy
Author: R. O'Toole
Author: J. Gilligan
Author: P. Prescott

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