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Efficient block designs for comparing dual with single treatments.

Record type: Article

Experiments in blocks having two treatment factors are considered in which a particular treatment must be excluded. The work is motivated by medical trials of two drugs in which a double placebo cannot be administered on ethical grounds. The contrasts of interest compare the effects of having both treatment factor at non-zero labelled levels with the effects of having only one treatment factor at a non-zero labelled level. For nx2 experiments, a class of designs containing highly efficient members is identified and a lower bound on the efficiencies of designs in this class is derived. Tables of efficient designs are provided.

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Citation

Gerami, A., Lewis, S.M., Majumdar, D. and Notz, W.I. (1998) Efficient block designs for comparing dual with single treatments. Journal of Statistical Planning and Inference, 72, (1), pp. 247-263. (doi:10.1016/S0378-3758(98)00035-4).

More information

Published date: 1998
Keywords: a-optimality, dual versus single treatment contrasts, factorial experiment, lower bound, part-balance
Organisations: Statistics

Identifiers

Local EPrints ID: 30060
URI: http://eprints.soton.ac.uk/id/eprint/30060
ISSN: 0378-3758
PURE UUID: b00668db-bef8-4d1f-9cda-0c34c2e2a0ad

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Date deposited: 14 Mar 2007
Last modified: 17 Jul 2017 15:55

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Contributors

Author: A. Gerami
Author: S.M. Lewis
Author: D. Majumdar
Author: W.I. Notz

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