The University of Southampton
University of Southampton Institutional Repository

Selecting closest to a control

Bofinger, E. and Liu, W. (2001) Selecting closest to a control Australian & New Zealand Journal of Statistics, 43, (4), pp. 421-430.

Record type: Article


Consider the usual one-way fixed effect analysis of variance model where the populations ?i(I = 0, 1, . . . , k) have independent normal distributions with unknown means and common unknown variance. Let ?0 be a control population with which the other (treatment) populations are to be compared. The basic problem is to select the treatment that is closest to the control mean. This situation occurs when one of the ?i must be chosen, regardless of how many are equivalent to the control in the sense of having means sufficiently close. This paper follows the approach of Hsu (1996) and is based on a set of simultaneous confidence intervals. It provides a table of critical values which allows direct implementation of the new inference procedure. The applications given are of the balanced cross-over design type with negligible carry-over effects, for which the results of this paper may be used. One of the applications refers to the selection of a drug, which may not be bioequivalent to a reference formulation but is the closest of those drugs that are readily available to the group of patients considered.

Full text not available from this repository.

More information

Published date: 2001
Keywords: bioequivalence, cross-over, equivalence, relative bioavailability, selection, simultaneous confidence intervals, subset selection
Organisations: Statistics


Local EPrints ID: 30104
ISSN: 1369-1473
PURE UUID: e8187521-ead3-4817-9067-0b4e8e4b136b
ORCID for W. Liu: ORCID iD

Catalogue record

Date deposited: 12 May 2006
Last modified: 17 Jul 2017 15:55

Export record


Author: E. Bofinger
Author: W. Liu ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.