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CCR7 is expressed in astrocytes and upregulated after an inflammatory injury

Record type: Article

Neurodegenerative or autoimmune diseases are frequently regulated by chemokines and their receptors, controlling both glial activation and immune cell infiltration. CCL19 and CCL21 have been described to mediate crucial functions during CNS pathological states, regulating both immune cell traffic to the CNS and communication between glia and neurons. Here, we describe the expression pattern and cellular sources of CCR7, receptor of CCL19 and CCL21, in the normal mouse brain. Moreover, we found that CCR7 is upregulated in reactive astrocytes upon intracerebral LPS, regulating early glial reactivity through its ligands CCL19 and CCL21. Our results indicate that CCR7 is playing an important role for the intercellular communication during the inflammatory activation in the CNS.

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Citation

Gomez-Nicola, Diego, Pallas-Bazarra, Noemí, Valle-Argos, Beatriz and Nieto-Sampedro, Manuel (2010) CCR7 is expressed in astrocytes and upregulated after an inflammatory injury Journal of Neuroimmunology, 227, (1-2), pp. 87-92. (doi:10.1016/j.jneuroim.2010.06.018). (PMID:20638137).

More information

e-pub ahead of print date: 16 July 2010
Published date: 8 October 2010
Keywords: CCR7, CCL19, CCL21, astrocyte, microglia, LPS
Organisations: Biomedicine

Identifiers

Local EPrints ID: 333250
URI: http://eprints.soton.ac.uk/id/eprint/333250
ISSN: 0165-5728
PURE UUID: b4df4fe1-4c66-41ea-9794-f9244b827241
ORCID for Diego Gomez-Nicola: ORCID iD orcid.org/0000-0002-5316-2682

Catalogue record

Date deposited: 06 Mar 2012 11:54
Last modified: 18 Jul 2017 06:13

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Contributors

Author: Noemí Pallas-Bazarra
Author: Beatriz Valle-Argos
Author: Manuel Nieto-Sampedro

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