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CCR7 is expressed in astrocytes and upregulated after an inflammatory injury

CCR7 is expressed in astrocytes and upregulated after an inflammatory injury
CCR7 is expressed in astrocytes and upregulated after an inflammatory injury
Neurodegenerative or autoimmune diseases are frequently regulated by chemokines and their receptors, controlling both glial activation and immune cell infiltration. CCL19 and CCL21 have been described to mediate crucial functions during CNS pathological states, regulating both immune cell traffic to the CNS and communication between glia and neurons. Here, we describe the expression pattern and cellular sources of CCR7, receptor of CCL19 and CCL21, in the normal mouse brain. Moreover, we found that CCR7 is upregulated in reactive astrocytes upon intracerebral LPS, regulating early glial reactivity through its ligands CCL19 and CCL21. Our results indicate that CCR7 is playing an important role for the intercellular communication during the inflammatory activation in the CNS.
CCR7, CCL19, CCL21, astrocyte, microglia, LPS
0165-5728
87-92
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Pallas-Bazarra, Noemí
76313982-288d-4747-b86a-897fe55b6a92
Valle-Argos, Beatriz
4fddaa71-c0aa-4b95-b464-8bdb592428a2
Nieto-Sampedro, Manuel
6d62c63e-e900-4219-b596-447dae4b0c2d
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Pallas-Bazarra, Noemí
76313982-288d-4747-b86a-897fe55b6a92
Valle-Argos, Beatriz
4fddaa71-c0aa-4b95-b464-8bdb592428a2
Nieto-Sampedro, Manuel
6d62c63e-e900-4219-b596-447dae4b0c2d

Gomez-Nicola, Diego, Pallas-Bazarra, Noemí, Valle-Argos, Beatriz and Nieto-Sampedro, Manuel (2010) CCR7 is expressed in astrocytes and upregulated after an inflammatory injury. Journal of Neuroimmunology, 227 (1-2), 87-92. (doi:10.1016/j.jneuroim.2010.06.018). (PMID:20638137)

Record type: Article

Abstract

Neurodegenerative or autoimmune diseases are frequently regulated by chemokines and their receptors, controlling both glial activation and immune cell infiltration. CCL19 and CCL21 have been described to mediate crucial functions during CNS pathological states, regulating both immune cell traffic to the CNS and communication between glia and neurons. Here, we describe the expression pattern and cellular sources of CCR7, receptor of CCL19 and CCL21, in the normal mouse brain. Moreover, we found that CCR7 is upregulated in reactive astrocytes upon intracerebral LPS, regulating early glial reactivity through its ligands CCL19 and CCL21. Our results indicate that CCR7 is playing an important role for the intercellular communication during the inflammatory activation in the CNS.

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More information

e-pub ahead of print date: 16 July 2010
Published date: 8 October 2010
Keywords: CCR7, CCL19, CCL21, astrocyte, microglia, LPS
Organisations: Biomedicine

Identifiers

Local EPrints ID: 333250
URI: https://eprints.soton.ac.uk/id/eprint/333250
ISSN: 0165-5728
PURE UUID: b4df4fe1-4c66-41ea-9794-f9244b827241
ORCID for Diego Gomez-Nicola: ORCID iD orcid.org/0000-0002-5316-2682

Catalogue record

Date deposited: 06 Mar 2012 11:54
Last modified: 06 Jun 2018 12:33

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