Glioma growth inhibition by neurostatin and O-But GD1b
Glioma growth inhibition by neurostatin and O-But GD1b
In spite of their low incidence, central nervous system tumors have elevated morbidity and mortality, being responsible for 2.3% of total cancer deaths. The ganglioside O-acetylated GD1b (O-Ac GD1b; neurostatin), present in the mammalian brain, and the semi-synthetic O-butyrylated GD1b (O-But GD1b) are potent glioma proliferation inhibitors, appearing as possible candidates for the treatment of nervous system tumors. Tumoral cell division inhibitory activity in culture correlated with growth inhibition of glioma xenotransplants in Foxn1(nu) nude mice and intracranial glioma allotransplants. Both O-Ac GD1b and O-But GD1b inhibited in vivo cell proliferation, induced cell cycle arrest, and potentiated immune cell response to the tumor. Furthermore, the increased stability of the butyrylated compound (O-But GD1b) enhanced its activity with respect to the acetylated ganglioside (neurostatin). These results are the first report of the antitumoral activity of neurostatin and a neurostatin-like compound in vivo and indicate that semi-synthetic O-acetylated and O-butyrylated gangliosides are potent antitumoral compounds that should be considered in strategies for brain tumor treatment.
C6 cells, gangliosides, glioma, neurostatin, O-But GD1b
1135-1146
Valle-Argos, Beatriz
4fddaa71-c0aa-4b95-b464-8bdb592428a2
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Nieto-Sampedro, Manuel
6d62c63e-e900-4219-b596-447dae4b0c2d
November 2010
Valle-Argos, Beatriz
4fddaa71-c0aa-4b95-b464-8bdb592428a2
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Nieto-Sampedro, Manuel
6d62c63e-e900-4219-b596-447dae4b0c2d
Valle-Argos, Beatriz, Gomez-Nicola, Diego and Nieto-Sampedro, Manuel
(2010)
Glioma growth inhibition by neurostatin and O-But GD1b.
Neuro-Oncology, 12 (11), .
(doi:10.1093/neuonc/noq073).
(PMID:20615925)
Abstract
In spite of their low incidence, central nervous system tumors have elevated morbidity and mortality, being responsible for 2.3% of total cancer deaths. The ganglioside O-acetylated GD1b (O-Ac GD1b; neurostatin), present in the mammalian brain, and the semi-synthetic O-butyrylated GD1b (O-But GD1b) are potent glioma proliferation inhibitors, appearing as possible candidates for the treatment of nervous system tumors. Tumoral cell division inhibitory activity in culture correlated with growth inhibition of glioma xenotransplants in Foxn1(nu) nude mice and intracranial glioma allotransplants. Both O-Ac GD1b and O-But GD1b inhibited in vivo cell proliferation, induced cell cycle arrest, and potentiated immune cell response to the tumor. Furthermore, the increased stability of the butyrylated compound (O-But GD1b) enhanced its activity with respect to the acetylated ganglioside (neurostatin). These results are the first report of the antitumoral activity of neurostatin and a neurostatin-like compound in vivo and indicate that semi-synthetic O-acetylated and O-butyrylated gangliosides are potent antitumoral compounds that should be considered in strategies for brain tumor treatment.
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e-pub ahead of print date: 8 July 2010
Published date: November 2010
Keywords:
C6 cells, gangliosides, glioma, neurostatin, O-But GD1b
Organisations:
Biomedicine
Identifiers
Local EPrints ID: 333252
URI: http://eprints.soton.ac.uk/id/eprint/333252
ISSN: 1522-8517
PURE UUID: 3be2e12d-1619-47cb-a618-37a4368afa32
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Date deposited: 06 Mar 2012 11:48
Last modified: 15 Mar 2024 03:37
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Author:
Beatriz Valle-Argos
Author:
Manuel Nieto-Sampedro
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