Valle-Argos, Beatriz, Gomez-Nicola, Diego and Nieto-Sampedro, Manuel
Synthesis and characterization of neurostatin-related compounds with high inhibitory activity of glioma growth
European Journal of Medicinal Chemistry, 45, (5), . (doi:10.1016/j.ejmech.2010.01.015). (PMID:20153569).
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O-acetyl-ganglioside neurostatin, (Galbeta1 -> 3GalNAcbeta1 -> 4[9-O-Ac Neu5Acalpha2 -> 8Neu5Acalpha2 -> 3]Galbeta1 -> 4Glcbeta1 -> 1'-ceramide), is a natural GD1b-derived inhibitor of astroblast and astrocytoma division, whose structure and purification method limits its availability and stability. Therefore, we set-up the reaction to obtain O-acetylated and O-butyrylated neurostatin analogs by chemical synthesis, in order to improve its availability and stability. The compounds antitumoral activity was evaluated on U373MG and C6 glioblastoma cells, observing that the O-acetylation-dependent increase in the inhibitory activity was enhanced by O-butyrylation, with no further improvement with the multi-substitution, pointing to the initial conformational change and the stability change as responsible of its function. These results open the possibility for the application of the neurostatin-related compounds to in-vivo tumoral models.
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