Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice
Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice
IL-15 initially identified as a T proliferating cytokine has several structural and biological similarities with IL-2 and has been associated with a number of autoimmune diseases. Because of the scarcity of information available on the role of IL-15 in MS pathogenesis, we have investigated how the absence of IL-15 affected the development of experimental autoimmune encephalomyelitis, a mouse model of MS. Following immunization of IL-15(-/-) and C57BL/6 mice with MOG(35-55), we observed a more severe neurological impairment in the IL-15 knockout mice than in the wild-type group. The enhanced disease severity in IL-15(-/-) mice was associated with greater demyelination in the spinal cord, increased immune cell infiltration and inflammation. These events may be related to the higher CD4/CD8 ratio and the almost absent NK cell activity, congenital immune features of IL-15KO mice. Moreover, we found that the fractalkine receptor CX3CR1 was overexpressed in the spinal cord of IL-15(-/-) mice, mainly localized on infiltrating CD8(+) T cells. How these findings are contributing to the aggravated EAE development in IL-15 KO mice remain unclear and need to be further investigated.
CD4, CD8, CX3CR1, multiple sclerosis, cytokines, demyelination
235-242
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Spagnolo, Alessandra
8e908374-e2ea-4081-8156-65db51d250db
Guaza, Carmen
da82c3f6-843c-478d-8856-2598b080eee6
Nieto-Sampedro, Manuel
6d62c63e-e900-4219-b596-447dae4b0c2d
April 2010
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Spagnolo, Alessandra
8e908374-e2ea-4081-8156-65db51d250db
Guaza, Carmen
da82c3f6-843c-478d-8856-2598b080eee6
Nieto-Sampedro, Manuel
6d62c63e-e900-4219-b596-447dae4b0c2d
Gomez-Nicola, Diego, Spagnolo, Alessandra, Guaza, Carmen and Nieto-Sampedro, Manuel
(2010)
Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice.
Experimental Neurology, 222 (2), .
(doi:10.1016/j.expneurol.2009.12.034).
(PMID:20070942)
Abstract
IL-15 initially identified as a T proliferating cytokine has several structural and biological similarities with IL-2 and has been associated with a number of autoimmune diseases. Because of the scarcity of information available on the role of IL-15 in MS pathogenesis, we have investigated how the absence of IL-15 affected the development of experimental autoimmune encephalomyelitis, a mouse model of MS. Following immunization of IL-15(-/-) and C57BL/6 mice with MOG(35-55), we observed a more severe neurological impairment in the IL-15 knockout mice than in the wild-type group. The enhanced disease severity in IL-15(-/-) mice was associated with greater demyelination in the spinal cord, increased immune cell infiltration and inflammation. These events may be related to the higher CD4/CD8 ratio and the almost absent NK cell activity, congenital immune features of IL-15KO mice. Moreover, we found that the fractalkine receptor CX3CR1 was overexpressed in the spinal cord of IL-15(-/-) mice, mainly localized on infiltrating CD8(+) T cells. How these findings are contributing to the aggravated EAE development in IL-15 KO mice remain unclear and need to be further investigated.
This record has no associated files available for download.
More information
e-pub ahead of print date: January 2010
Published date: April 2010
Keywords:
CD4, CD8, CX3CR1, multiple sclerosis, cytokines, demyelination
Organisations:
Biomedicine
Identifiers
Local EPrints ID: 333258
URI: http://eprints.soton.ac.uk/id/eprint/333258
ISSN: 0014-4886
PURE UUID: 4caf296d-6665-41fc-a654-62b73625a38c
Catalogue record
Date deposited: 02 Mar 2012 16:58
Last modified: 15 Mar 2024 03:37
Export record
Altmetrics
Contributors
Author:
Alessandra Spagnolo
Author:
Carmen Guaza
Author:
Manuel Nieto-Sampedro
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics