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Interleukin 15 expression in the CNS: blockade of its activity prevents glial activation after an inflammatory injury.

Gomez-Nicola, Diego, Valle-Argos, Beatriz, Pita-Thomas, D Wolfgang and Nieto-Sampedro, Manuel (2008) Interleukin 15 expression in the CNS: blockade of its activity prevents glial activation after an inflammatory injury. Glia, 56, (5), pp. 494-505. (doi:10.1002/glia.20628). (PMID:18240307).

Record type: Article

Abstract

Although reactive glia formation after neuronal degeneration or traumatic damage is one of the hallmarks of central nervous system (CNS) injury, we have little information on the signals that direct activation of resting glia. IL-15, a pro-inflammatory cytokine involved in regulating the response of T and B cells, may be also key for the regulation of early inflammatory events in the nervous system. IL-15 was expressed in the CNS, most abundantly in cerebellum and hippocampus, mainly in astrocytes and in some projection neurons. Using a rodent model of acute inflammatory injury [lipopolysaccharide (LPS) injection], we found enhanced expression of IL-15 in both reactive astroglia and microglia, soon after CNS injury. Blockade of IL-15 activity with an antibody to the cytokine, reversed activation of both glial types, suggesting that IL-15 has a major role in the generation of gliotic tissue and in the regulation of neuroimmune responses. Because IL-15 appears to modulate the inflammatory environment acutely generated after CNS injury, regulating IL-15 expression seems a clear antiinflammatory therapy to improve the outcome of neurodegenerative diseases and CNS trauma.

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More information

e-pub ahead of print date: 31 January 2008
Published date: 1 April 2008
Keywords: cytokines, IL-15, inflammation, lipopolysaccharide, microglia, astrocytes
Organisations: Biomedicine

Identifiers

Local EPrints ID: 333264
URI: http://eprints.soton.ac.uk/id/eprint/333264
ISSN: 0894-1491
PURE UUID: c47909ce-0bde-4a32-b01a-888cfc6201b0
ORCID for Diego Gomez-Nicola: ORCID iD orcid.org/0000-0002-5316-2682

Catalogue record

Date deposited: 02 Mar 2012 16:34
Last modified: 18 Jul 2017 06:13

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Contributors

Author: Beatriz Valle-Argos
Author: D Wolfgang Pita-Thomas
Author: Manuel Nieto-Sampedro

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