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Contrast agent-free cell sonoporation using a continuous-flow microfluidic device

Carugo, Dario, Ankrett, Dyan N., Glynne-Jones, Peter, Capretto, Lorenzo, Boltryk, Rosemary J., Townsend, Paul A., Zhang, Xunli and Hill, Martyn (2011) Contrast agent-free cell sonoporation using a continuous-flow microfluidic device At The 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS ), United States. 02 Oct 2011 - 06 Oct 2012 .

Record type: Conference or Workshop Item (Paper)

Abstract

Ultrasound (US) has been utilised to induce reversible poration of cell membranes (sonoporation) in order to facilitate the trans-membrane delivery of pharmaceutical agents. Sonoporation is conventionally performed in the presence of microbubble contrast agents (CA). However, challenges remain in achieving controlled sonoporation due to CA cavitational effects, which can significantly reduce cell viability. Therefore CA-free sonoporation represents a “gentle” methodology for facilitating the delivery of pharmaceutical agents while maintaining high cell viability. We report facilitated uptake of doxorubicin and apigenin by CA free sonoporation of suspended cardiomyocytes by generating an ultrasonic standing wave within an easy to-use continuous-flow microfluidic device

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More information

Published date: October 2011
Venue - Dates: The 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS ), United States, 2011-10-02 - 2012-10-06
Organisations: Cancer Sciences, Bioengineering Group, Mechatronics

Identifiers

Local EPrints ID: 333944
URI: http://eprints.soton.ac.uk/id/eprint/333944
PURE UUID: a21b892f-a7c8-4cf2-996d-053b0a286542
ORCID for Peter Glynne-Jones: ORCID iD orcid.org/0000-0001-5684-3953
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448

Catalogue record

Date deposited: 08 Mar 2012 11:44
Last modified: 18 Jul 2017 06:12

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Contributors

Author: Dario Carugo
Author: Dyan N. Ankrett
Author: Lorenzo Capretto
Author: Rosemary J. Boltryk
Author: Paul A. Townsend
Author: Xunli Zhang
Author: Martyn Hill ORCID iD

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