Contrast agent-free cell sonoporation using a continuous-flow microfluidic device


Carugo, Dario, Ankrett, Dyan N., Glynne-Jones, Peter, Capretto, Lorenzo, Boltryk, Rosemary J., Townsend, Paul A., Zhang, Xunli and Hill, Martyn (2011) Contrast agent-free cell sonoporation using a continuous-flow microfluidic device At The 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS ), United States. 02 Oct 2011 - 06 Oct 2012 .

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Description/Abstract

Ultrasound (US) has been utilised to induce reversible poration of cell membranes (sonoporation) in order to facilitate the trans-membrane delivery of pharmaceutical agents. Sonoporation is conventionally performed in the presence of microbubble contrast agents (CA). However, challenges remain in achieving controlled sonoporation due to CA cavitational effects, which can significantly reduce cell viability. Therefore CA-free sonoporation represents a “gentle” methodology for facilitating the delivery of pharmaceutical agents while maintaining high cell viability. We report facilitated uptake of doxorubicin and apigenin by CA free sonoporation of suspended cardiomyocytes by generating an ultrasonic standing wave within an easy to-use continuous-flow microfluidic device

Item Type: Conference or Workshop Item (Paper)
Venue - Dates: The 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS ), United States, 2011-10-02 - 2012-10-06
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Organisations: Cancer Sciences, Bioengineering Group, Mechatronics
ePrint ID: 333944
Date :
Date Event
October 2011Published
Date Deposited: 08 Mar 2012 11:44
Last Modified: 17 Apr 2017 17:28
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/333944

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