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High frequency of loss of heterozygosity in actinic keratoses, a usually benign disease

Record type: Article

Actinic keratoses (AKs) are focal areas of dysplasia with low risk of progression to squamous cell cancer; many regress spontaneously. Using polymerase-chain-reaction microsatellite analysis, we found that loss of heterozygosity on several chromosome arms, including 17p, 17q, 9p, 9q, and 13q, was common in AKs. More than half the AKs examined showed loss of heterozygosity at four or more loci. The apparent genetic instability of these lesions contrasts with their benign clinical course.

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Citation

Rehman, I., Quinn, A.G., Healy, E. and Rees, J.L. (1994) High frequency of loss of heterozygosity in actinic keratoses, a usually benign disease The Lancet, 344, (8925), pp. 788-789. (doi:10.1016/S0140-6736(94)92343-4). (PMID:7916075).

More information

Published date: 17 September 1994
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 334152
URI: http://eprints.soton.ac.uk/id/eprint/334152
ISSN: 0140-6736
PURE UUID: 7c0983c9-abd0-4c8c-9038-4ba9d3a9d2e3

Catalogue record

Date deposited: 16 Mar 2012 09:54
Last modified: 18 Jul 2017 06:12

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Contributors

Author: I. Rehman
Author: A.G. Quinn
Author: E. Healy
Author: J.L. Rees

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