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Prognostic value of Ki67 antigen expression in basal cell carcinomas

Prognostic value of Ki67 antigen expression in basal cell carcinomas
Prognostic value of Ki67 antigen expression in basal cell carcinomas
Recurrence of basal cell carcinoma (BCC) following treatment is a common event and long-term follow-up of all patients presenting with a primary BCC has been recommended. Proliferation indices have been recognized as important prognostic factors in several tumour types in a variety of cancer systems, being significantly elevated in more aggressive lesions. We have examined 51 BCCs (17 non-recurrent tumours [group 1], 17 original tumours which later recurred [group 2-O], and the corresponding 17 recurrent specimens [group 2-R]) for Ki67 antigen expression, a proliferation-associated antigen using immunohistochemistry with the monoclonal antibody MIB1. There was a significant increase in the percentage positive for MIB1 in the Group 2-O as compared with the group 1 BCCs (P<0.05). p53 protein expression, as assessed by immunohistochemistry with the monoclonal antibody DO7, was similar in each group. These results show that Ki67 antigen expression differs between BCCs which later recur and BCCs that do not recur.
0007-0963
737-741
Healy, E.
400fc04d-f81a-474a-ae25-7ff894be0ebd
Angus, B.
899f2303-e814-4e39-ab5b-da7306cfdac5
Lawrence, C.M.
c1eab9bb-933d-4b69-81ed-203a6464170e
Rees, J.L.
4884fa5d-84c0-45da-b2a3-a096bfd21c9b
Healy, E.
400fc04d-f81a-474a-ae25-7ff894be0ebd
Angus, B.
899f2303-e814-4e39-ab5b-da7306cfdac5
Lawrence, C.M.
c1eab9bb-933d-4b69-81ed-203a6464170e
Rees, J.L.
4884fa5d-84c0-45da-b2a3-a096bfd21c9b

(1995) Prognostic value of Ki67 antigen expression in basal cell carcinomas. British Journal of Dermatology, 133 (5), 737-741. (doi:10.1111/j.1365-2133.1995.tb02748.x). (PMID:8555026)

Record type: Article

Abstract

Recurrence of basal cell carcinoma (BCC) following treatment is a common event and long-term follow-up of all patients presenting with a primary BCC has been recommended. Proliferation indices have been recognized as important prognostic factors in several tumour types in a variety of cancer systems, being significantly elevated in more aggressive lesions. We have examined 51 BCCs (17 non-recurrent tumours [group 1], 17 original tumours which later recurred [group 2-O], and the corresponding 17 recurrent specimens [group 2-R]) for Ki67 antigen expression, a proliferation-associated antigen using immunohistochemistry with the monoclonal antibody MIB1. There was a significant increase in the percentage positive for MIB1 in the Group 2-O as compared with the group 1 BCCs (P<0.05). p53 protein expression, as assessed by immunohistochemistry with the monoclonal antibody DO7, was similar in each group. These results show that Ki67 antigen expression differs between BCCs which later recur and BCCs that do not recur.

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Published date: November 1995
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 334164
URI: http://eprints.soton.ac.uk/id/eprint/334164
ISSN: 0007-0963
PURE UUID: 83ff93e7-7a21-4c63-9bf7-216e6cd73f14

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Date deposited: 16 Mar 2012 10:17
Last modified: 18 Jul 2017 06:12

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