The University of Southampton
University of Southampton Institutional Repository

Prognostic significance of allelic losses in primary melanoma

Prognostic significance of allelic losses in primary melanoma
Prognostic significance of allelic losses in primary melanoma
Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine whether allelic loss is of prognostic importance in melanoma, disease-free survival was related to loss of heterozygosity on 6q, 9p and 10q in 83 individuals with sporadic primary cutaneous melanoma. Loss of chromosome arms 6q and 10q were each significantly associated with a poorer clinical outcome (P=0.013 and P=0.001 respectively). In a subgroup of 41 subjects whose primary tumours were allelotyped, the fractional allelic loss (FAL) at 39 autosomal arms also significantly correlated with disease-free survival (P=0.013), with an increase in FAL associated with a poorer outcome; this association remained significant when controlled for tumour thickness (P=0.035). In addition, a greater proportion of cells were immunopositive for Ki67 antigen, p53 and p21WAF1 protein in the primary melanomas than in the benign melanocytic nevi, however, only p53 over-expression was significantly associated with improved survival (P=0.041).
loss of heterozygosity, fractional allelic loss, tumour suppressor gene, proliferation
0950-9232
2213-2218
Healy, Eugene
Belgaid, Christine
fa913291-e79e-4dd8-b191-6867f65cd4d7
Takata, Minoru
25b5b6fe-2f22-4ef0-aebf-b010d77f8e37
Harrison, David
864be260-5888-46c3-a883-c683bd9bcc98
Zhu, Ning Wen
6a90acf7-48ed-494d-9ab1-376b1ee070ee
Burd, D, Andrew R.
517a655f-cc08-4b9c-b730-54cc27c22e06
Rigby, Howard S.
abe2b9c6-dec5-428f-8bdc-52fdf5047c7f
Matthews, John N. S.
9aa54b66-2926-400f-bf0c-1e6208f4ab53
Rees, Jonathan L.
8a58a967-d239-4300-b363-ca471bf7047f
Healy, Eugene
Belgaid, Christine
fa913291-e79e-4dd8-b191-6867f65cd4d7
Takata, Minoru
25b5b6fe-2f22-4ef0-aebf-b010d77f8e37
Harrison, David
864be260-5888-46c3-a883-c683bd9bcc98
Zhu, Ning Wen
6a90acf7-48ed-494d-9ab1-376b1ee070ee
Burd, D, Andrew R.
517a655f-cc08-4b9c-b730-54cc27c22e06
Rigby, Howard S.
abe2b9c6-dec5-428f-8bdc-52fdf5047c7f
Matthews, John N. S.
9aa54b66-2926-400f-bf0c-1e6208f4ab53
Rees, Jonathan L.
8a58a967-d239-4300-b363-ca471bf7047f

Healy, Eugene, Belgaid, Christine, Takata, Minoru, Harrison, David, Zhu, Ning Wen, Burd, D, Andrew R., Rigby, Howard S., Matthews, John N. S. and Rees, Jonathan L. (1998) Prognostic significance of allelic losses in primary melanoma. Oncogene, 16 (17), 2213-2218. (PMID:9619830)

Record type: Article

Abstract

Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine whether allelic loss is of prognostic importance in melanoma, disease-free survival was related to loss of heterozygosity on 6q, 9p and 10q in 83 individuals with sporadic primary cutaneous melanoma. Loss of chromosome arms 6q and 10q were each significantly associated with a poorer clinical outcome (P=0.013 and P=0.001 respectively). In a subgroup of 41 subjects whose primary tumours were allelotyped, the fractional allelic loss (FAL) at 39 autosomal arms also significantly correlated with disease-free survival (P=0.013), with an increase in FAL associated with a poorer outcome; this association remained significant when controlled for tumour thickness (P=0.035). In addition, a greater proportion of cells were immunopositive for Ki67 antigen, p53 and p21WAF1 protein in the primary melanomas than in the benign melanocytic nevi, however, only p53 over-expression was significantly associated with improved survival (P=0.041).

This record has no associated files available for download.

More information

Published date: 30 April 1998
Keywords: loss of heterozygosity, fractional allelic loss, tumour suppressor gene, proliferation
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 334244
URI: http://eprints.soton.ac.uk/id/eprint/334244
ISSN: 0950-9232
PURE UUID: 575673fe-e69f-4d69-8bdf-ee4c5b10d70f

Catalogue record

Date deposited: 16 Mar 2012 10:30
Last modified: 22 Jul 2022 18:01

Export record

Contributors

Author: Eugene Healy
Author: Christine Belgaid
Author: Minoru Takata
Author: David Harrison
Author: Ning Wen Zhu
Author: D, Andrew R. Burd
Author: Howard S. Rigby
Author: John N. S. Matthews
Author: Jonathan L. Rees

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×