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Melanocortin 1 receptor gene and sun sensitivity in individuals without red hair

Melanocortin 1 receptor gene and sun sensitivity in individuals without red hair
Melanocortin 1 receptor gene and sun sensitivity in individuals without red hair
Susceptibility to sunburn, photoageing, and skin cancer is
inversely related to an individual’s ability to tan after sun
exposure. We examined variants in the melanocortin-1-receptor
(MC1R) gene in individuals from Ireland and the UK. We found
evidence of an association between the degree of tanning after
repeated sun exposure, and the number of variant alleles
present. Heterozygotes were intermediate between wild-type
individuals and those with two variant alleles. We suggest that
MC1R gene status therefore determines sun sensitivity in
people without red hair.
0140-6736
1072-1073
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Flanagan, Niamh
2d37f079-81df-4145-8833-5cfa215c215d
Ray, Amanda
541e873e-6ff6-427a-8044-f6852b46de89
Todd, Carole
842f0b28-f5b7-4af2-8ad8-5f2b2aa5f395
Jackson, Ian J.
deb175b7-f77e-4b60-b8a9-472ef9cb6770
Matthews, John N. S.
9aa54b66-2926-400f-bf0c-1e6208f4ab53
Birch-Machin, Mark A.
1bd387dd-9082-40bf-8ab3-f898bc68fc76
Rees, Jonathan L.
8a58a967-d239-4300-b363-ca471bf7047f
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Flanagan, Niamh
2d37f079-81df-4145-8833-5cfa215c215d
Ray, Amanda
541e873e-6ff6-427a-8044-f6852b46de89
Todd, Carole
842f0b28-f5b7-4af2-8ad8-5f2b2aa5f395
Jackson, Ian J.
deb175b7-f77e-4b60-b8a9-472ef9cb6770
Matthews, John N. S.
9aa54b66-2926-400f-bf0c-1e6208f4ab53
Birch-Machin, Mark A.
1bd387dd-9082-40bf-8ab3-f898bc68fc76
Rees, Jonathan L.
8a58a967-d239-4300-b363-ca471bf7047f

Healy, Eugene, Flanagan, Niamh, Ray, Amanda, Todd, Carole, Jackson, Ian J., Matthews, John N. S., Birch-Machin, Mark A. and Rees, Jonathan L. (2000) Melanocortin 1 receptor gene and sun sensitivity in individuals without red hair. The Lancet, 355 (9209), 1072-1073. (PMID:10744096)

Record type: Article

Abstract

Susceptibility to sunburn, photoageing, and skin cancer is
inversely related to an individual’s ability to tan after sun
exposure. We examined variants in the melanocortin-1-receptor
(MC1R) gene in individuals from Ireland and the UK. We found
evidence of an association between the degree of tanning after
repeated sun exposure, and the number of variant alleles
present. Heterozygotes were intermediate between wild-type
individuals and those with two variant alleles. We suggest that
MC1R gene status therefore determines sun sensitivity in
people without red hair.

Full text not available from this repository.

More information

Published date: 25 March 2000
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 334304
URI: https://eprints.soton.ac.uk/id/eprint/334304
ISSN: 0140-6736
PURE UUID: 3c3d706f-fee3-4901-9e81-a1c5e05f5e82

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Date deposited: 08 Mar 2012 12:53
Last modified: 05 Oct 2018 12:10

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