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A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme

A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme
A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme
Background: Low muscle mass and function have been associated with poorer indicators of physical capability in older
people, which are in-turn associated with increased mortality rates. The growth hormone/insulin-like growth factor (GH/IGF)
axis is involved in muscle function and genetic variants in genes in the axis may influence measures of physical capability.
Methods: As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women from seven UK
cohorts aged between 52 and 90 years old were genotyped for six polymorphisms: rs35767 (IGF1), rs7127900 (IGF2),
rs2854744 (IGFBP3), rs2943641 (IRS1), rs2665802 (GH1) and the exon-3 deletion of GHR. The polymorphisms have previously
been robustly associated with age-related traits or are potentially functional. Meta-analysis was used to pool within-study
genotypic effects of the associations between the polymorphisms and four measures of physical capability: grip strength,
timed walk or get up and go, chair rises and standing balance.
Results: Few important associations were observed among the several tests. We found evidence that rs2665802 in GH1 was
associated with inability to balance for 5 s (pooled odds ratio per minor allele = 0.90, 95% CI: 0.82–0.98, p-value = 0.01,
n = 10,748), after adjusting for age and sex. We found no evidence for other associations between the polymorphisms and
physical capability traits.
Conclusion: Our findings do not provide evidence for a substantial influence of these common polymorphisms in the GH/
IGF axis on objectively measured physical capability levels in older adults.
1932-6203
e29883
Alfred, Tamuno
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Ben-Shlomo, Yoav
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Cooper, Rachel
24a4a55a-ccc1-4961-9b76-b89aa4eb2fdf
Hardy, Rebecca
99fecbaf-fc92-4354-aa02-cb904dd2bd32
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
Gaunt, Tom R.
ff4bc39d-405c-4ba1-896b-7e7d2f747387
Gunnell, David
d525f7e5-7447-43c8-84b7-a122b60b3c54
Harris, Sarah E.
925adc32-c478-44a2-84c0-1c7eefa8dfc8
Kumari, Meena
fc42bd66-3f7c-4f72-8f7b-d9cb40900b3d
Martin, Richard M.
ce5c4184-4432-4435-bd1e-221f665d42d8
Sayer, Avan Aihie
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Starr, John M.
92fc6cf8-b0f7-47dc-93d8-8fd246d40585
Kuh, Diana
4f3b51aa-21a0-4d68-be14-e1ed75448aaf
Day, Ian N. M.
4a300555-7eea-4f61-926e-3cdfb0fd78fe
Alfred, Tamuno
a74abf26-a2cf-4a0d-9abf-6e9507cfad7a
Ben-Shlomo, Yoav
df80bd02-a908-4296-b293-825d42203729
Cooper, Rachel
24a4a55a-ccc1-4961-9b76-b89aa4eb2fdf
Hardy, Rebecca
99fecbaf-fc92-4354-aa02-cb904dd2bd32
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
Gaunt, Tom R.
ff4bc39d-405c-4ba1-896b-7e7d2f747387
Gunnell, David
d525f7e5-7447-43c8-84b7-a122b60b3c54
Harris, Sarah E.
925adc32-c478-44a2-84c0-1c7eefa8dfc8
Kumari, Meena
fc42bd66-3f7c-4f72-8f7b-d9cb40900b3d
Martin, Richard M.
ce5c4184-4432-4435-bd1e-221f665d42d8
Sayer, Avan Aihie
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Starr, John M.
92fc6cf8-b0f7-47dc-93d8-8fd246d40585
Kuh, Diana
4f3b51aa-21a0-4d68-be14-e1ed75448aaf
Day, Ian N. M.
4a300555-7eea-4f61-926e-3cdfb0fd78fe

Alfred, Tamuno, Ben-Shlomo, Yoav, Cooper, Rachel, Hardy, Rebecca, Cooper, C., Deary, Ian J., Gaunt, Tom R., Gunnell, David, Harris, Sarah E., Kumari, Meena, Martin, Richard M., Sayer, Avan Aihie, Starr, John M., Kuh, Diana and Day, Ian N. M. (2012) A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme. PLoS ONE, 7 (1), e29883. (doi:10.1371/journal.pone.0029883). (PMID:22253814)

Record type: Article

Abstract

Background: Low muscle mass and function have been associated with poorer indicators of physical capability in older
people, which are in-turn associated with increased mortality rates. The growth hormone/insulin-like growth factor (GH/IGF)
axis is involved in muscle function and genetic variants in genes in the axis may influence measures of physical capability.
Methods: As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women from seven UK
cohorts aged between 52 and 90 years old were genotyped for six polymorphisms: rs35767 (IGF1), rs7127900 (IGF2),
rs2854744 (IGFBP3), rs2943641 (IRS1), rs2665802 (GH1) and the exon-3 deletion of GHR. The polymorphisms have previously
been robustly associated with age-related traits or are potentially functional. Meta-analysis was used to pool within-study
genotypic effects of the associations between the polymorphisms and four measures of physical capability: grip strength,
timed walk or get up and go, chair rises and standing balance.
Results: Few important associations were observed among the several tests. We found evidence that rs2665802 in GH1 was
associated with inability to balance for 5 s (pooled odds ratio per minor allele = 0.90, 95% CI: 0.82–0.98, p-value = 0.01,
n = 10,748), after adjusting for age and sex. We found no evidence for other associations between the polymorphisms and
physical capability traits.
Conclusion: Our findings do not provide evidence for a substantial influence of these common polymorphisms in the GH/
IGF axis on objectively measured physical capability levels in older adults.

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Published date: 10 January 2012
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 334408
URI: https://eprints.soton.ac.uk/id/eprint/334408
ISSN: 1932-6203
PURE UUID: c914553d-aad1-452a-8f73-2848064b5927
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 08 Mar 2012 12:31
Last modified: 19 Nov 2019 01:56

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Contributors

Author: Tamuno Alfred
Author: Yoav Ben-Shlomo
Author: Rachel Cooper
Author: Rebecca Hardy
Author: C. Cooper ORCID iD
Author: Ian J. Deary
Author: Tom R. Gaunt
Author: David Gunnell
Author: Sarah E. Harris
Author: Meena Kumari
Author: Richard M. Martin
Author: John M. Starr
Author: Diana Kuh
Author: Ian N. M. Day

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