Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial
Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial
The osteoporosis drug strontium ranelate dissociates bone remodelling processes. It also inhibits subchondral bone resorption and stimulates cartilage matrix formation in vitro. Exploratory studies in the osteoporosis trials report that strontium ranelate reduces biomarkers of cartilage degradation, and attenuates the progression and clinical symptoms of spinal osteoarthritis, suggesting symptom- and structure-modifying activity in osteoarthritis. We describe the rationale and design of a randomised trial evaluating the efficacy and safety of strontium ranelate in knee osteoarthritis.
231-239
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Reginster, J.Y.
4083b457-5347-4ece-a53e-af19c8868c42
Chapurlat, R.
9435221c-55dc-4b28-a6ee-4b2a05b35674
Christiansen, C.
b1993f77-2024-4daf-b5d8-1ce837315564
Genant, H.
d5e63c14-a724-4233-9b54-6c9354b9ffe7
Bellamy, N.
1836247b-d9da-435b-90e0-d6761fbfde11
Bensen, W.
f87ef2e3-802d-42d7-a682-bda893966a23
Navarro, F.
87661e1a-6cf6-4d50-a8f1-db2eac5f04af
Badurski, J.
f5a0d8fa-48e2-4fdd-a99a-9f0c69d0bd39
Nasonov, E.
9657e345-deab-4171-984e-603035ecbc60
Chevalier, X.
c1ff9aea-e2ee-4c00-a499-70d892d3c428
Sambrook, P.N.
b2d6bdaa-7a4e-4785-b668-e8abd39e36b4
February 2010
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Reginster, J.Y.
4083b457-5347-4ece-a53e-af19c8868c42
Chapurlat, R.
9435221c-55dc-4b28-a6ee-4b2a05b35674
Christiansen, C.
b1993f77-2024-4daf-b5d8-1ce837315564
Genant, H.
d5e63c14-a724-4233-9b54-6c9354b9ffe7
Bellamy, N.
1836247b-d9da-435b-90e0-d6761fbfde11
Bensen, W.
f87ef2e3-802d-42d7-a682-bda893966a23
Navarro, F.
87661e1a-6cf6-4d50-a8f1-db2eac5f04af
Badurski, J.
f5a0d8fa-48e2-4fdd-a99a-9f0c69d0bd39
Nasonov, E.
9657e345-deab-4171-984e-603035ecbc60
Chevalier, X.
c1ff9aea-e2ee-4c00-a499-70d892d3c428
Sambrook, P.N.
b2d6bdaa-7a4e-4785-b668-e8abd39e36b4
Cooper, C., Reginster, J.Y., Chapurlat, R., Christiansen, C., Genant, H., Bellamy, N., Bensen, W., Navarro, F., Badurski, J., Nasonov, E., Chevalier, X. and Sambrook, P.N.
(2010)
Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial.
Current Medical Research and Opinion, 28 (2), .
(doi:10.1185/03007995.2011.648758).
(PMID:22148897)
Abstract
The osteoporosis drug strontium ranelate dissociates bone remodelling processes. It also inhibits subchondral bone resorption and stimulates cartilage matrix formation in vitro. Exploratory studies in the osteoporosis trials report that strontium ranelate reduces biomarkers of cartilage degradation, and attenuates the progression and clinical symptoms of spinal osteoarthritis, suggesting symptom- and structure-modifying activity in osteoarthritis. We describe the rationale and design of a randomised trial evaluating the efficacy and safety of strontium ranelate in knee osteoarthritis.
This record has no associated files available for download.
More information
Published date: February 2010
Organisations:
Faculty of Health Sciences
Identifiers
Local EPrints ID: 334508
URI: http://eprints.soton.ac.uk/id/eprint/334508
ISSN: 0300-7995
PURE UUID: 02cdcef3-6469-44ab-b99b-fd0bd3c33309
Catalogue record
Date deposited: 08 Mar 2012 10:29
Last modified: 18 Mar 2024 02:45
Export record
Altmetrics
Contributors
Author:
J.Y. Reginster
Author:
R. Chapurlat
Author:
C. Christiansen
Author:
H. Genant
Author:
N. Bellamy
Author:
W. Bensen
Author:
F. Navarro
Author:
J. Badurski
Author:
E. Nasonov
Author:
X. Chevalier
Author:
P.N. Sambrook
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
