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Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial

Cooper, C., Reginster, J.Y., Chapurlat, R., Christiansen, C., Genant, H., Bellamy, N., Bensen, W., Navarro, F., Badurski, J., Nasonov, E., Chevalier, X. and Sambrook, P.N. (2010) Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial Current Medical Research and Opinion, 28, (2), pp. 231-239. (doi:10.1185/03007995.2011.648758). (PMID:22148897).

Record type: Article

Abstract

The osteoporosis drug strontium ranelate dissociates bone remodelling processes. It also inhibits subchondral bone resorption and stimulates cartilage matrix formation in vitro. Exploratory studies in the osteoporosis trials report that strontium ranelate reduces biomarkers of cartilage degradation, and attenuates the progression and clinical symptoms of spinal osteoarthritis, suggesting symptom- and structure-modifying activity in osteoarthritis. We describe the rationale and design of a randomised trial evaluating the efficacy and safety of strontium ranelate in knee osteoarthritis.



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Published date: February 2010
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 334508
URI: http://eprints.soton.ac.uk/id/eprint/334508
ISSN: 0300-7995
PURE UUID: 02cdcef3-6469-44ab-b99b-fd0bd3c33309
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 08 Mar 2012 10:29
Last modified: 18 Jul 2017 06:11

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Contributors

Author: C. Cooper ORCID iD
Author: J.Y. Reginster
Author: R. Chapurlat
Author: C. Christiansen
Author: H. Genant
Author: N. Bellamy
Author: W. Bensen
Author: F. Navarro
Author: J. Badurski
Author: E. Nasonov
Author: X. Chevalier
Author: P.N. Sambrook

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