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Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience

Record type: Article

Natural killer (NK) cells mediate innate defense against viral infections, but the mechanisms in place to access their functions as needed during diverse challenges while limiting collateral damage are poorly understood. Recent molecular characterization of effects mediated through infection-induced inhibitory/activating NK receptor-ligand pairs and cytokines are providing new insights into pathways regulating their responses and revealing unexpected consequences for NK cell subset effects, maintenance, proliferation and function through times overlapping with adaptive and long-lived immunity. The observations define flexible pathways for experience-induced "conditioning" and challenge narrowly defined roles for NK cells and innate immunity as first responders with prescribed functions. They suggest that individual experiences as well as genes influence the innate immune resources available to fight off an infection.

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Citation

Vidal, Silvia M., Khakoo, Salim I. and Biron, Christine A. (2011) Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience Current Opinion in Virology, 1, (6), pp. 497-512. (doi:10.1016/j.coviro.2011.10.017). (PMID:22180766).

More information

e-pub ahead of print date: 17 November 2011
Published date: 1 December 2011
Keywords: natural killer (NK) cells, virology
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 336167
URI: http://eprints.soton.ac.uk/id/eprint/336167
PURE UUID: 8b35d6a2-84a4-4181-8756-fe83db4b5ae0

Catalogue record

Date deposited: 16 Mar 2012 11:13
Last modified: 18 Jul 2017 06:09

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Contributors

Author: Silvia M. Vidal
Author: Salim I. Khakoo
Author: Christine A. Biron

University divisions


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