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Natural killer cells and hepatitis C: action and reaction

Record type: Article

In 1989, hepatitis C virus (HCV) was first identified as the infectious agent responsible for human non-A, non-B hepatitis. Two decades later, HCV remains a global public health problem with a suboptimal response rate to treatment and the absence of a protective vaccine. Recent work has highlighted the influence of the innate immune system, and in particular natural killer cells, on the outcome and pathology of HCV infection. These cells are considerably more complex than was originally thought and their role in viral infections is currently being unravelled. This review summarises our emerging understanding of natural killer cells in HCV infection.

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Citation

Cheent, Kuldeep and Khakoo, Salim I. (2011) Natural killer cells and hepatitis C: action and reaction Gut, 60, (2), pp. 268-278. (doi:10.1136/gut.2010.212555). (PMID:20876777).

More information

Published date: February 2011
Keywords: natural killer cells, immunology, hepatitis C
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 336177
URI: http://eprints.soton.ac.uk/id/eprint/336177
ISSN: 0017-5749
PURE UUID: 4e38d9a4-894b-4eb9-b623-b9e5f8a0ca45

Catalogue record

Date deposited: 16 Mar 2012 12:55
Last modified: 18 Jul 2017 06:09

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Contributors

Author: Kuldeep Cheent
Author: Salim I. Khakoo

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