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Natural killer cells: integrating diversity with function

Natural killer cells: integrating diversity with function
Natural killer cells: integrating diversity with function
The key role of natural killer cells in many aspects of the immune response is now being recognized. The last decade has seen an exponential increase in our understanding of the workings of these cells. Receptor diversity is crucial in allowing natural killer cells to respond effectively to a variety of different pathogens. This article reviews aspects of natural killer cell diversity that combine to generate populations of functional natural killer cells that exist within both the individual and throughout the population at large.
diversity, integration, KIR, NK cells, receptors, signalling
0019-2805
449-457
Cheent, Kuldeep
fc998259-3582-4bb3-ae11-58e418666bbc
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Cheent, Kuldeep
fc998259-3582-4bb3-ae11-58e418666bbc
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273

Cheent, Kuldeep and Khakoo, Salim I. (2009) Natural killer cells: integrating diversity with function. Immunology, 126 (4), 449-457. (doi:10.1111/j.1365-2567.2009.03045.x). (PMID:19278418)

Record type: Article

Abstract

The key role of natural killer cells in many aspects of the immune response is now being recognized. The last decade has seen an exponential increase in our understanding of the workings of these cells. Receptor diversity is crucial in allowing natural killer cells to respond effectively to a variety of different pathogens. This article reviews aspects of natural killer cell diversity that combine to generate populations of functional natural killer cells that exist within both the individual and throughout the population at large.

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More information

Published date: April 2009
Keywords: diversity, integration, KIR, NK cells, receptors, signalling
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 336185
URI: http://eprints.soton.ac.uk/id/eprint/336185
DOI: doi:10.1111/j.1365-2567.2009.03045.x
ISSN: 0019-2805
PURE UUID: 8ac34711-2c71-4545-9b2d-ff9f5c16bb07
ORCID for Salim I. Khakoo: ORCID iD orcid.org/0000-0002-4057-9091

Catalogue record

Date deposited: 16 Mar 2012 14:41
Last modified: 15 Mar 2024 03:12

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Contributors

Author: Kuldeep Cheent
Author: Salim I. Khakoo ORCID iD

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