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Speed and selection in the evolution of killer-cell immunoglobulin-like receptors

Speed and selection in the evolution of killer-cell immunoglobulin-like receptors
Speed and selection in the evolution of killer-cell immunoglobulin-like receptors
The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selection of their MHC class I ligands. Human KIR diversity is now a burgeoning area for disease association studies. This review examines the evolution of KIR from a primate-centric view in order to rationalize our current knowledge of the diversity of human KIR.
KIR receptors, natural killer cells
1744-3121
89-96
Martinez-Borra, J.
352867a4-a135-49b0-a5d7-45d91c5228a1
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Martinez-Borra, J.
352867a4-a135-49b0-a5d7-45d91c5228a1
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273

Martinez-Borra, J. and Khakoo, Salim I. (2008) Speed and selection in the evolution of killer-cell immunoglobulin-like receptors. International Journal of Immunogenetics, 35 (2), 89-96. (doi:10.1111/j.1744-313X.2008.00756.x). (PMID:18279370)

Record type: Article

Abstract

The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selection of their MHC class I ligands. Human KIR diversity is now a burgeoning area for disease association studies. This review examines the evolution of KIR from a primate-centric view in order to rationalize our current knowledge of the diversity of human KIR.

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More information

e-pub ahead of print date: 12 February 2008
Published date: April 2008
Keywords: KIR receptors, natural killer cells
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 336186
URI: http://eprints.soton.ac.uk/id/eprint/336186
DOI: doi:10.1111/j.1744-313X.2008.00756.x
ISSN: 1744-3121
PURE UUID: fa0dbb54-2ffe-41e2-a757-e81db0806257
ORCID for Salim I. Khakoo: ORCID iD orcid.org/0000-0002-4057-9091

Catalogue record

Date deposited: 16 Mar 2012 15:20
Last modified: 15 Mar 2024 03:12

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Contributors

Author: J. Martinez-Borra
Author: Salim I. Khakoo ORCID iD

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