The University of Southampton
University of Southampton Institutional Repository

Speed and selection in the evolution of killer-cell immunoglobulin-like receptors

Martinez-Borra, J. and Khakoo, Salim I. (2008) Speed and selection in the evolution of killer-cell immunoglobulin-like receptors International Journal of Immunogenetics, 35, (2), pp. 89-96. (doi:10.1111/j.1744-313X.2008.00756.x). (PMID:18279370).

Record type: Article


The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selection of their MHC class I ligands. Human KIR diversity is now a burgeoning area for disease association studies. This review examines the evolution of KIR from a primate-centric view in order to rationalize our current knowledge of the diversity of human KIR.

Full text not available from this repository.

More information

e-pub ahead of print date: 12 February 2008
Published date: April 2008
Keywords: KIR receptors, natural killer cells
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 336186
ISSN: 1744-3121
PURE UUID: fa0dbb54-2ffe-41e2-a757-e81db0806257

Catalogue record

Date deposited: 16 Mar 2012 15:20
Last modified: 18 Jul 2017 06:09

Export record



Author: J. Martinez-Borra
Author: Salim I. Khakoo

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.