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Speed and selection in the evolution of killer-cell immunoglobulin-like receptors

Record type: Article

The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selection of their MHC class I ligands. Human KIR diversity is now a burgeoning area for disease association studies. This review examines the evolution of KIR from a primate-centric view in order to rationalize our current knowledge of the diversity of human KIR.

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Citation

Martinez-Borra, J. and Khakoo, Salim I. (2008) Speed and selection in the evolution of killer-cell immunoglobulin-like receptors International Journal of Immunogenetics, 35, (2), pp. 89-96. (doi:10.1111/j.1744-313X.2008.00756.x). (PMID:18279370).

More information

e-pub ahead of print date: 12 February 2008
Published date: April 2008
Keywords: KIR receptors, natural killer cells
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 336186
URI: http://eprints.soton.ac.uk/id/eprint/336186
ISSN: 1744-3121
PURE UUID: fa0dbb54-2ffe-41e2-a757-e81db0806257

Catalogue record

Date deposited: 16 Mar 2012 15:20
Last modified: 18 Jul 2017 06:09

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Contributors

Author: J. Martinez-Borra
Author: Salim I. Khakoo

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