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Thin film polycrystalline silicon nanowire biosensors

Record type: Article

Polysilicon nanowire biosensors have been fabricated using a top-down process and were used to determine the binding constant of two inflammatory biomarkers. A very low cost nanofabrication process was developed, based on simple and mature photolithography, thin film technology and plasma etching, enabling an easy route to mass manufacture. Antibodyfunctionalized nanowire sensors were used to detect the proteins interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) over a wide range of concentrations, demonstrating excellent sensitivity and selectivity, exemplified by a detection sensitivity of 10fM in the presence of a 100,000-fold excess of a non-target protein. Nanowire titration curves gave antibody-antigen dissociation constants in good agreement with low-salt enzyme-linked immunosorbent assays (ELISAs). This fabrication process produces high-quality nanowires that are suitable for lowcost mass production, providing a realistic route to the realization of disposable nanoelectronic Point-of-Care (PoC) devices.

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Citation

Al Hakim, Mohammad M., Lombardini, Marta, Sun, Kai, Giustiniano, Francesco, Roach, Peter L., Davies, Donna E., Howarth, Peter H., de Planque, Maurits R.R., Morgan, Hywel and Ashburn, Peter (2012) Thin film polycrystalline silicon nanowire biosensors Nano Letters, 12, (4), pp. 1868-1872. (doi:10.1021/nl2042276). (PMID:22432636).

More information

Published date: 20 March 2012
Organisations: Nanoelectronics and Nanotechnology, Organic Chemistry: SCF, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 336302
URI: http://eprints.soton.ac.uk/id/eprint/336302
ISSN: 1530-6984
PURE UUID: 8c4d3bef-4669-4224-a6ff-6e317353e5f2
ORCID for Francesco Giustiniano: ORCID iD orcid.org/0000-0001-9277-8538
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 21 Mar 2012 13:33
Last modified: 18 Jul 2017 06:08

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Contributors

Author: Mohammad M. Al Hakim
Author: Marta Lombardini
Author: Kai Sun
Author: Francesco Giustiniano ORCID iD
Author: Peter L. Roach
Author: Donna E. Davies
Author: Hywel Morgan ORCID iD
Author: Peter Ashburn

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