Squaramides as potent transmembrane anion transporters

Busschaert, Nathalie, Kirby, Isabelle L., Young, Sarah, Coles, Simon J., Horton, Peter N., Light, Mark E. and Gale, Philip A. (2012) Squaramides as potent transmembrane anion transporters Angewandte Chemie International Edition, 51, (18), pp. 4426-4430. (doi:10.1002/anie.201200729).


Full text not available from this repository.


Square peg in a round ball: squaramides are shown to be potent transmembrane anion transporters for both chloride and bicarbonate, performing better than the thiourea and urea analogues. Studies into the nature of this transport point to a mobile carrier mechanism, where the squaramide delivers the anion cargo across the lipid bilayer (see scheme, green sphere=anion). These drug-like molecules provide a platform for the development of a new generation of anion-transport systems.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/anie.201200729
ISSNs: 1433-7851 (print)
Keywords: anion transport, anions, fluorinated ligands, squaramides, supramolecular chemistry
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow
ePrint ID: 336576
Date :
Date Event
27 March 2012Published
Date Deposited: 30 Mar 2012 11:55
Last Modified: 17 Apr 2017 17:21
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/336576

Actions (login required)

View Item View Item