The University of Southampton
University of Southampton Institutional Repository

Squaramides as potent transmembrane anion transporters

Busschaert, Nathalie, Kirby, Isabelle L., Young, Sarah, Coles, Simon J., Horton, Peter N., Light, Mark E. and Gale, Philip A. (2012) Squaramides as potent transmembrane anion transporters Angewandte Chemie International Edition, 51, (18), pp. 4426-4430. (doi:10.1002/anie.201200729).

Record type: Article


Square peg in a round ball: squaramides are shown to be potent transmembrane anion transporters for both chloride and bicarbonate, performing better than the thiourea and urea analogues. Studies into the nature of this transport point to a mobile carrier mechanism, where the squaramide delivers the anion cargo across the lipid bilayer (see scheme, green sphere=anion). These drug-like molecules provide a platform for the development of a new generation of anion-transport systems.

Full text not available from this repository.

More information

Published date: 27 March 2012
Keywords: anion transport, anions, fluorinated ligands, squaramides, supramolecular chemistry
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow


Local EPrints ID: 336576
ISSN: 1433-7851
PURE UUID: 70d4b3fc-e133-45da-9659-4dd430ada432
ORCID for Simon J. Coles: ORCID iD
ORCID for Peter N. Horton: ORCID iD
ORCID for Mark E. Light: ORCID iD
ORCID for Philip A. Gale: ORCID iD

Catalogue record

Date deposited: 30 Mar 2012 11:55
Last modified: 18 Jul 2017 06:07

Export record



Author: Nathalie Busschaert
Author: Isabelle L. Kirby
Author: Sarah Young
Author: Simon J. Coles ORCID iD
Author: Peter N. Horton ORCID iD
Author: Mark E. Light ORCID iD
Author: Philip A. Gale ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.