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Squaramides as potent transmembrane anion transporters

Squaramides as potent transmembrane anion transporters
Squaramides as potent transmembrane anion transporters
Square peg in a round ball: squaramides are shown to be potent transmembrane anion transporters for both chloride and bicarbonate, performing better than the thiourea and urea analogues. Studies into the nature of this transport point to a mobile carrier mechanism, where the squaramide delivers the anion cargo across the lipid bilayer (see scheme, green sphere=anion). These drug-like molecules provide a platform for the development of a new generation of anion-transport systems.
anion transport, anions, fluorinated ligands, squaramides, supramolecular chemistry
1433-7851
4426-4430
Busschaert, Nathalie
bf307f09-0a86-4a03-afd8-4b0a59a8f72b
Kirby, Isabelle L.
5839d488-f346-4741-b757-9ecf30777938
Young, Sarah
073f2ac4-c635-4857-955b-8f8f6fb044cf
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Horton, Peter N.
154c8930-bfc3-495b-ad4a-8a278d5da3a5
Light, Mark E.
cf57314e-6856-491b-a8d2-2dffc452e161
Gale, Philip A.
c840b7e9-6847-4843-91af-fa0f8563d943
Busschaert, Nathalie
bf307f09-0a86-4a03-afd8-4b0a59a8f72b
Kirby, Isabelle L.
5839d488-f346-4741-b757-9ecf30777938
Young, Sarah
073f2ac4-c635-4857-955b-8f8f6fb044cf
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Horton, Peter N.
154c8930-bfc3-495b-ad4a-8a278d5da3a5
Light, Mark E.
cf57314e-6856-491b-a8d2-2dffc452e161
Gale, Philip A.
c840b7e9-6847-4843-91af-fa0f8563d943

Busschaert, Nathalie, Kirby, Isabelle L., Young, Sarah, Coles, Simon J., Horton, Peter N., Light, Mark E. and Gale, Philip A. (2012) Squaramides as potent transmembrane anion transporters. Angewandte Chemie International Edition, 51 (18), 4426-4430. (doi:10.1002/anie.201200729).

Record type: Article

Abstract

Square peg in a round ball: squaramides are shown to be potent transmembrane anion transporters for both chloride and bicarbonate, performing better than the thiourea and urea analogues. Studies into the nature of this transport point to a mobile carrier mechanism, where the squaramide delivers the anion cargo across the lipid bilayer (see scheme, green sphere=anion). These drug-like molecules provide a platform for the development of a new generation of anion-transport systems.

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More information

Published date: 27 March 2012
Keywords: anion transport, anions, fluorinated ligands, squaramides, supramolecular chemistry
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow

Identifiers

Local EPrints ID: 336576
URI: https://eprints.soton.ac.uk/id/eprint/336576
ISSN: 1433-7851
PURE UUID: 70d4b3fc-e133-45da-9659-4dd430ada432
ORCID for Simon J. Coles: ORCID iD orcid.org/0000-0001-8414-9272
ORCID for Peter N. Horton: ORCID iD orcid.org/0000-0001-8886-2016
ORCID for Mark E. Light: ORCID iD orcid.org/0000-0002-0585-0843
ORCID for Philip A. Gale: ORCID iD orcid.org/0000-0001-9751-4910

Catalogue record

Date deposited: 30 Mar 2012 11:55
Last modified: 19 Nov 2019 01:53

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