Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products
aldol reaction, fused-ring systems, heterocycles, isoxazole, metalation, pyridone
308-312
Jones, Raymond C F
fb3eb3ed-9655-42d4-928e-0ecf4f5ab369
Choudhury, Abdul K
78d32d90-ac44-488b-93fd-7c6a93a8b29d
Iley, James N
c64b3ff6-378f-4427-99fc-a5f07aec5782
Light, Mark E
cf57314e-6856-491b-a8d2-2dffc452e161
Loizou, Georgia
005c0eb9-f657-40ef-b59e-1fb18b3c05cd
Pillainayagam, Terence A
1b8a40cf-03c5-483d-a568-a05a26f8344e
27 February 2012
Jones, Raymond C F
fb3eb3ed-9655-42d4-928e-0ecf4f5ab369
Choudhury, Abdul K
78d32d90-ac44-488b-93fd-7c6a93a8b29d
Iley, James N
c64b3ff6-378f-4427-99fc-a5f07aec5782
Light, Mark E
cf57314e-6856-491b-a8d2-2dffc452e161
Loizou, Georgia
005c0eb9-f657-40ef-b59e-1fb18b3c05cd
Pillainayagam, Terence A
1b8a40cf-03c5-483d-a568-a05a26f8344e
Jones, Raymond C F, Choudhury, Abdul K, Iley, James N, Light, Mark E, Loizou, Georgia and Pillainayagam, Terence A
(2012)
Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones.
Beilstein Journal of Organic Chemistry, 8, .
(doi:10.3762/bjoc.8.33).
Abstract
A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products
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Published date: 27 February 2012
Keywords:
aldol reaction, fused-ring systems, heterocycles, isoxazole, metalation, pyridone
Organisations:
Chemistry
Identifiers
Local EPrints ID: 336655
URI: http://eprints.soton.ac.uk/id/eprint/336655
ISSN: 1860-5397
PURE UUID: d864cafe-f724-4511-92e2-df876c9458f4
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Date deposited: 02 Apr 2012 15:07
Last modified: 15 Mar 2024 03:01
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Contributors
Author:
Raymond C F Jones
Author:
Abdul K Choudhury
Author:
James N Iley
Author:
Georgia Loizou
Author:
Terence A Pillainayagam
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