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Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones

Record type: Article

A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products

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Citation

Jones, Raymond C F, Choudhury, Abdul K, Iley, James N, Light, Mark E, Loizou, Georgia and Pillainayagam, Terence A (2012) Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones Beilstein Journal of Organic Chemistry, 8, pp. 308-312. (doi:10.3762/bjoc.8.33).

More information

Published date: 27 February 2012
Keywords: aldol reaction, fused-ring systems, heterocycles, isoxazole, metalation, pyridone
Organisations: Chemistry

Identifiers

Local EPrints ID: 336655
URI: http://eprints.soton.ac.uk/id/eprint/336655
ISSN: 1860-5397
PURE UUID: d864cafe-f724-4511-92e2-df876c9458f4
ORCID for Mark E Light: ORCID iD orcid.org/0000-0002-0585-0843

Catalogue record

Date deposited: 02 Apr 2012 15:07
Last modified: 18 Jul 2017 06:06

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Contributors

Author: Raymond C F Jones
Author: Abdul K Choudhury
Author: James N Iley
Author: Mark E Light ORCID iD
Author: Georgia Loizou
Author: Terence A Pillainayagam

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