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Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones

Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products
aldol reaction, fused-ring systems, heterocycles, isoxazole, metalation, pyridone
1860-5397
308-312
Jones, Raymond C F
fb3eb3ed-9655-42d4-928e-0ecf4f5ab369
Choudhury, Abdul K
78d32d90-ac44-488b-93fd-7c6a93a8b29d
Iley, James N
c64b3ff6-378f-4427-99fc-a5f07aec5782
Light, Mark E
cf57314e-6856-491b-a8d2-2dffc452e161
Loizou, Georgia
005c0eb9-f657-40ef-b59e-1fb18b3c05cd
Pillainayagam, Terence A
1b8a40cf-03c5-483d-a568-a05a26f8344e
Jones, Raymond C F
fb3eb3ed-9655-42d4-928e-0ecf4f5ab369
Choudhury, Abdul K
78d32d90-ac44-488b-93fd-7c6a93a8b29d
Iley, James N
c64b3ff6-378f-4427-99fc-a5f07aec5782
Light, Mark E
cf57314e-6856-491b-a8d2-2dffc452e161
Loizou, Georgia
005c0eb9-f657-40ef-b59e-1fb18b3c05cd
Pillainayagam, Terence A
1b8a40cf-03c5-483d-a568-a05a26f8344e

Jones, Raymond C F, Choudhury, Abdul K, Iley, James N, Light, Mark E, Loizou, Georgia and Pillainayagam, Terence A (2012) Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones. Beilstein Journal of Organic Chemistry, 8, 308-312. (doi:10.3762/bjoc.8.33).

Record type: Article

Abstract

A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products

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Published date: 27 February 2012
Keywords: aldol reaction, fused-ring systems, heterocycles, isoxazole, metalation, pyridone
Organisations: Chemistry

Identifiers

Local EPrints ID: 336655
URI: http://eprints.soton.ac.uk/id/eprint/336655
ISSN: 1860-5397
PURE UUID: d864cafe-f724-4511-92e2-df876c9458f4
ORCID for Mark E Light: ORCID iD orcid.org/0000-0002-0585-0843

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Date deposited: 02 Apr 2012 15:07
Last modified: 18 Feb 2021 16:52

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Contributors

Author: Raymond C F Jones
Author: Abdul K Choudhury
Author: James N Iley
Author: Mark E Light ORCID iD
Author: Georgia Loizou
Author: Terence A Pillainayagam

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