Programmable one-pot multistep organic synthesis using DNA junctions
Programmable one-pot multistep organic synthesis using DNA junctions
A system for multistep DNA-templated synthesis is controlled by the sequential formation of DNA junctions. Reactants are attached to DNA adapters which are brought together by hybridization to DNA template strands. This process can be repeated to allow sequence-controlled oligomer synthesis while maintaining a constant reaction environment, independent of oligomer length, at each reaction step. Synthesis can take place in a single pot containing all required reactive monomers. Different oligomers can be synthesized in parallel in the same vessel, and the products of parallel synthesis can be ligated, reducing the number of reaction steps required to produce an oligomer of a given length
1446-1449
McKee, Mireya L.
189d4b60-90b1-4e2f-b95e-2c534bc89087
Milnes, Phillip J.
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Bath, Jonathan
fc276b69-5e06-43e9-a3d5-d7324bc23267
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
O’Reilly, Rachel K.
a8e21e94-1cc2-4a07-8a5d-5a76a17adf2a
Turberfield, Andrew J.
e12469b0-4ae6-44a5-9099-e9273ab803d4
January 2012
McKee, Mireya L.
189d4b60-90b1-4e2f-b95e-2c534bc89087
Milnes, Phillip J.
fcb9cc31-266f-477a-ab39-a32793470c0a
Bath, Jonathan
fc276b69-5e06-43e9-a3d5-d7324bc23267
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
O’Reilly, Rachel K.
a8e21e94-1cc2-4a07-8a5d-5a76a17adf2a
Turberfield, Andrew J.
e12469b0-4ae6-44a5-9099-e9273ab803d4
McKee, Mireya L., Milnes, Phillip J., Bath, Jonathan, Stulz, Eugen, O’Reilly, Rachel K. and Turberfield, Andrew J.
(2012)
Programmable one-pot multistep organic synthesis using DNA junctions.
Journal of the American Chemical Society, 134 (3), .
(doi:10.1021/ja2101196).
Abstract
A system for multistep DNA-templated synthesis is controlled by the sequential formation of DNA junctions. Reactants are attached to DNA adapters which are brought together by hybridization to DNA template strands. This process can be repeated to allow sequence-controlled oligomer synthesis while maintaining a constant reaction environment, independent of oligomer length, at each reaction step. Synthesis can take place in a single pot containing all required reactive monomers. Different oligomers can be synthesized in parallel in the same vessel, and the products of parallel synthesis can be ligated, reducing the number of reaction steps required to produce an oligomer of a given length
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Published date: January 2012
Organisations:
Molecular Diagnostics & Thereputics
Identifiers
Local EPrints ID: 336788
URI: http://eprints.soton.ac.uk/id/eprint/336788
ISSN: 0002-7863
PURE UUID: 39d8462f-6594-4337-b19a-82c2a4fd5727
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Date deposited: 11 Apr 2012 10:04
Last modified: 15 Mar 2024 03:26
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Contributors
Author:
Mireya L. McKee
Author:
Phillip J. Milnes
Author:
Jonathan Bath
Author:
Rachel K. O’Reilly
Author:
Andrew J. Turberfield
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