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Programmable one-pot multistep organic synthesis using DNA junctions

McKee, Mireya L., Milnes, Phillip J., Bath, Jonathan, Stulz, Eugen, O’Reilly, Rachel K. and Turberfield, Andrew J. (2012) Programmable one-pot multistep organic synthesis using DNA junctions Journal of the American Chemical Society, 134, (3), pp. 1446-1449. (doi:10.1021/ja2101196).

Record type: Article


A system for multistep DNA-templated synthesis is controlled by the sequential formation of DNA junctions. Reactants are attached to DNA adapters which are brought together by hybridization to DNA template strands. This process can be repeated to allow sequence-controlled oligomer synthesis while maintaining a constant reaction environment, independent of oligomer length, at each reaction step. Synthesis can take place in a single pot containing all required reactive monomers. Different oligomers can be synthesized in parallel in the same vessel, and the products of parallel synthesis can be ligated, reducing the number of reaction steps required to produce an oligomer of a given length

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Published date: January 2012
Organisations: Molecular Diagnostics & Thereputics


Local EPrints ID: 336788
ISSN: 0002-7863
PURE UUID: 39d8462f-6594-4337-b19a-82c2a4fd5727

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Date deposited: 11 Apr 2012 10:04
Last modified: 18 Jul 2017 06:06

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Author: Mireya L. McKee
Author: Phillip J. Milnes
Author: Jonathan Bath
Author: Eugen Stulz
Author: Rachel K. O’Reilly
Author: Andrew J. Turberfield

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