How evolutionary principles improve the understanding of human health and disease

Gluckman, Peter D., Low, Felicia M., Buklijas, Tatjana, Hanson, Mark A. and Beedle, Alan S. (2011) How evolutionary principles improve the understanding of human health and disease [in special issue: In the light of evolution: interdisciplinary challenges in food, health, and the environment] Evolutionary Applications, 4, (2), pp. 249-263. (doi:10.1111/j.1752-4571.2010.00164.x).


Full text not available from this repository.


An appreciation of the fundamental principles of evolutionary biology provides new insights into major diseases and enables an integrated understanding of human biology and medicine. However, there is a lack of awareness of their importance amongst physicians, medical researchers, and educators, all of whom tend to focus on the mechanistic (proximate) basis for disease, excluding consideration of evolutionary (ultimate) reasons. The key principles of evolutionary medicine are that selection acts on fitness, not health or longevity; that our evolutionary history does not cause disease, but rather impacts on our risk of disease in particular environments; and that we are now living in novel environments compared to those in which we evolved. We consider these evolutionary principles in conjunction with population genetics and describe several pathways by which evolutionary processes can affect disease risk. These perspectives provide a more cohesive framework for gaining insights into the determinants of health and disease. Coupled with complementary insights offered by advances in genomic, epigenetic, and developmental biology research, evolutionary perspectives offer an important addition to understanding disease. Further, there are a number of aspects of evolutionary medicine that can add considerably to studies in other domains of contemporary evolutionary studies

Item Type: Article
Digital Object Identifier (DOI): doi:10.1111/j.1752-4571.2010.00164.x
ISSNs: 1752-4563 (print)
Keywords: contemporary evolution, developmental plasticity, epigenetics, evolutionary medicine, life history, mismatch, selection, trade-off
Organisations: Human Development & Health
ePrint ID: 337150
Date :
Date Event
17 February 2011e-pub ahead of print
March 2011Published
Date Deposited: 19 Apr 2012 14:05
Last Modified: 17 Apr 2017 17:18
Further Information:Google Scholar

Actions (login required)

View Item View Item