The University of Southampton
University of Southampton Institutional Repository

Targeting Mnks for cancer therapy

Hou, Jinqiang, Lam, Frankie, Proud, Christopher and Wang, Shudong (2012) Targeting Mnks for cancer therapy Oncotarget, 3, (2), pp. 118-131. (PMID:22392765).

Record type: Article

Abstract

Deregulation of protein synthesis is a common event in human cancer and a key player in translational control is eIF4E. Elevated expression levels of eIF4E promote cancer development and progression. Recent findings suggest that eIF4E activity is a key determinant of the PI3K/Akt/mTOR and Ras/Raf/MEK/ERK mediated tumorigenic activity and targeting eIF4E should have a major impact on these pathways in human cancer. The function of eIF4E is modulated through phosphorylation of a conserved serine (Ser209) by Mnk1 and Mnk2 downstream of ERK. While the phosphorylation event is necessary for oncogenic transformation, it seems to be dispensable for normal development. Hence, pharmacologic Mnk inhibitors may provide non-toxic and effective anti-cancer strategy. Strong circumstantial evidence indicates that Mnk inhibition presents attractive therapeutic potential, but the lack of selective Mnk inhibitors has so far confounded pharmacological target validation and clinical development.

Full text not available from this repository.

More information

Published date: February 2012
Keywords: eIF4E, Mnk, Ras, Raf, MAPK, Akt, PI3K, mTOR, targeted cancer therapy, structure based drug design, Mnk inhibitors
Organisations: Molecular and Cellular

Identifiers

Local EPrints ID: 337174
URI: http://eprints.soton.ac.uk/id/eprint/337174
ISSN: 1949-2553
PURE UUID: a94780d9-6cee-4c69-964e-a95aa1675d29

Catalogue record

Date deposited: 20 Apr 2012 09:24
Last modified: 18 Jul 2017 06:04

Export record

Contributors

Author: Jinqiang Hou
Author: Frankie Lam
Author: Christopher Proud
Author: Shudong Wang

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×