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Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing

Rodrigues, Hosana G., Vinolo, Marco Aurelio, Magdalon, Juliana, Vitzel, Kaio, Nachbar, Renato T., Pessoa, Ana Flavia, dos Santos, Marinilce F., Hatanaka, Elaine, Calder, Philip C. and Curi, Rui (2012) Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing Journal of Investigative Dermatology, 132, (1), pp. 208-215. (doi:10.1038/jid.2011.265). (PMID:21881592).

Record type: Article

Abstract

The effects of oral ingestion of oleic (OLA) and linoleic (LNA) acids on wound healing in rats were investigated. LNA increased the influx of inflammatory cells, the concentration of hydrogen peroxide (H2O2) and cytokine-induced neutrophil chemoattractant-2?? (CINC-2??), and the activation of the transcription factor activator protein-1 (AP-1) in the wound at 1?hour post wounding. LNA decreased the number of inflammatory cells and IL-1, IL-6, and macrophage inflammatory protein-3 (MIP-3) concentrations, as well as NF-?B activation in the wound at 24?hours post wounding. LNA accelerated wound closure over a period of 7 days. OLA increased TNF-? concentration and NF-?B activation at 1?hour post wounding. A reduction of IL-1, IL-6, and MIP-3? concentrations, as well as NF-?B activation, was observed 24?hours post wounding in the OLA group. These data suggest that OLA and LNA accelerate the inflammatory phase of wound healing, but that they achieve this through different mechanisms

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e-pub ahead of print date: 1 September 2011
Published date: January 2012
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 337195
URI: http://eprints.soton.ac.uk/id/eprint/337195
ISSN: 0022-202X
PURE UUID: 9daa3241-85ab-4dcb-9a66-f755b7416d21

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Date deposited: 20 Apr 2012 09:06
Last modified: 18 Jul 2017 06:04

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Contributors

Author: Hosana G. Rodrigues
Author: Marco Aurelio Vinolo
Author: Juliana Magdalon
Author: Kaio Vitzel
Author: Renato T. Nachbar
Author: Ana Flavia Pessoa
Author: Marinilce F. dos Santos
Author: Elaine Hatanaka
Author: Rui Curi

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