The University of Southampton
University of Southampton Institutional Repository

Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing

Rodrigues, Hosana G., Vinolo, Marco Aurelio, Magdalon, Juliana, Vitzel, Kaio, Nachbar, Renato T., Pessoa, Ana Flavia, dos Santos, Marinilce F., Hatanaka, Elaine, Calder, Philip C. and Curi, Rui (2012) Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing Journal of Investigative Dermatology, 132, (1), pp. 208-215. (doi:10.1038/jid.2011.265). (PMID:21881592).

Record type: Article


The effects of oral ingestion of oleic (OLA) and linoleic (LNA) acids on wound healing in rats were investigated. LNA increased the influx of inflammatory cells, the concentration of hydrogen peroxide (H2O2) and cytokine-induced neutrophil chemoattractant-2?? (CINC-2??), and the activation of the transcription factor activator protein-1 (AP-1) in the wound at 1?hour post wounding. LNA decreased the number of inflammatory cells and IL-1, IL-6, and macrophage inflammatory protein-3 (MIP-3) concentrations, as well as NF-?B activation in the wound at 24?hours post wounding. LNA accelerated wound closure over a period of 7 days. OLA increased TNF-? concentration and NF-?B activation at 1?hour post wounding. A reduction of IL-1, IL-6, and MIP-3? concentrations, as well as NF-?B activation, was observed 24?hours post wounding in the OLA group. These data suggest that OLA and LNA accelerate the inflammatory phase of wound healing, but that they achieve this through different mechanisms

Full text not available from this repository.

More information

e-pub ahead of print date: 1 September 2011
Published date: January 2012
Organisations: Human Development & Health


Local EPrints ID: 337195
ISSN: 0022-202X
PURE UUID: 9daa3241-85ab-4dcb-9a66-f755b7416d21

Catalogue record

Date deposited: 20 Apr 2012 09:06
Last modified: 18 Jul 2017 06:04

Export record



Author: Hosana G. Rodrigues
Author: Marco Aurelio Vinolo
Author: Juliana Magdalon
Author: Kaio Vitzel
Author: Renato T. Nachbar
Author: Ana Flavia Pessoa
Author: Marinilce F. dos Santos
Author: Elaine Hatanaka
Author: Rui Curi

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.