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The effect of nutrition during early life on the epigenetic regulation of transcription and implications for human diseases

Lillycrop, Karen A. and Burdge, Graham C. (2011) The effect of nutrition during early life on the epigenetic regulation of transcription and implications for human diseases Journal of Nutrigenetics and Nutrigenomics, 4, (5), pp. 248-260. (doi:10.1159/000334857). (PMID:22353662).

Record type: Article


Epigenetic processes which include DNA methylation, histone modification and miRNAs are integral in determining when and where specific genes are expressed. There is now increasing evidence that the epigenome is susceptible to a variety of environmental cues, such as nutrition, during specific periods of development. The changes induced by early-life nutrition may reflect an adaptive response of the foetus to environmental cues acting through the process of developmental plasticity. This may allow an organism to adjust its developmental programme resulting in long-term changes in its metabolism and physiology in order to be better matched to the future environment. However, when the future environment lies outside the anticipated range, metabolic and homoeostatic capacity will be mismatched with the environment and that individual will be at increased risk of developing a range of non-communicable diseases. Thus the environmental regulation of epigenetic processes is a central component in the developmental origins of non-communicable diseases and our understanding of these processes is, therefore, critical both for the identification of individuals at risk and for the development of new intervention strategies.

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Published date: 2011
Keywords: early life, epigenetics, nutrition, transcription
Organisations: Human Development & Health


Local EPrints ID: 337212
ISSN: 1661-6499
PURE UUID: abde1d94-ab93-4df6-bc51-ed8fcc751d43
ORCID for Karen A. Lillycrop: ORCID iD
ORCID for Graham C. Burdge: ORCID iD

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Date deposited: 20 Apr 2012 10:10
Last modified: 18 Jul 2017 06:04

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